| Gene Information | |
|---|---|
| Gene Name | LRRC32 |
| Organism | Homo sapiens (Human) |
| Gene Length | 662 |
| Protein Names | Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32) |
| Target Name | transforming growth factor beta activator lrrc32 |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000137507 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14392 |
| Gene Card | LRRC32 |
| Uniprot ID | Q14392 |
| Pfam | PF13855; PF01462 |
| In ASD | no |
| Allosteric Prediction | no (-0.582287479) |
| Ortholog in Animals | Alpaca_ LRRC32 ( ortholog_one2one ) Dog_ LRRC32 ( ortholog_one2one ) GuineaPig_ LRRC32 ( ortholog_one2one ) Macaque_ LRRC32 ( ortholog_one2one ) Mouse_ Lrrc32 ( ortholog_one2one ) Pig_ LRRC32 ( ortholog_one2one ) Rat_ Lrrc32 ( ortholog_one2one ) Rabbit_ LRRC32 ( ortholog_one2one ) |
| Ohnologs | TLR3 |
| Paralogs | CD180, RXFP1, TLR8, NRROS, TLR5, TSKU, TLR7, TLR10, RXFP2, TLR6, LRRC3B, IGFALS, TLR3, TLR2, TLR4, LRRC17, LRRC53, VASN, TLR1, LRRC3C, LRRC3, LRIT2 |
| Tissue | NA |
| Tissue Specificity | Preferentially expressed in regulatory T-cells (Tregs). {ECO:0000269|PubMed:18628982, ECO:0000269|PubMed:19750484, ECO:0000269|PubMed:21615933}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.4(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6GFF (X-ray 3.10A ) |
| DBSNP | rs35033061 rs35130967 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19651619, ECO:0000269|PubMed:19750484}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:19651619, ECO:0000269|PubMed:19750484}. |
| Mouse PG classification | NA |
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