| Gene Information | |
|---|---|
| Gene Name | EFP |
| Organism | Homo sapiens (Human) |
| Gene Length | 630 |
| Protein Names | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q14258 |
| Gene Card | TRIM25 |
| Uniprot ID | Q14258 |
| Pfam | PF13765; PF00622; PF13445 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in breast tumors (at protein level). Ubiquitous. {ECO:0000269|PubMed:15130519, ECO:0000269|PubMed:22452784}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001390(Rat);0.037037(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4CFG (X-ray 2.80A ) 4LTB (X-ray 2.59A ) 5EYA (X-ray 2.40A ) 5FER (X-ray 2.34A ) 5NT1 (X-ray 2.82A ) 5NT2 (X-ray 4.26A ) 6FLM (X-ray 2.01A ) 6FLN (X-ray 3.60A ) |
| DBSNP | rs7212260 rs205498 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17392790}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23950712}. Nucleus {ECO:0000250|UniProtKB:Q61510}. |
| Mouse PG classification | NA |
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