| Gene Information | |
|---|---|
| Gene Name | FCRL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 734 |
| Protein Names | Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000160856 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96P31 |
| Gene Card | FCRL3 |
| Uniprot ID | Q96P31 |
| Pfam | PF00047; PF13895 |
| In ASD | no |
| Allosteric Prediction | no (-0.646386226) |
| Ortholog in Animals | Alpaca_ FCRL3 ( ortholog_one2one ) Macaque_ FCRL3 ( ortholog_one2one ) Pig_ FCRL3 ( ortholog_one2one ) Rabbit_ FCRL3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PECAM1, MILR1, FCRL2, C17orf99, FCGR3B, FCRL5, FCRLA, FCGR2A, FCRLB, FCRL4, FCGR2B, FCGR3A, FCGR1A, FCER1A, FCGR2C, FCRL6, FCRL1 |
| Tissue | lymph.node, spleen, appendix, tonsil |
| Tissue Specificity | Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Low expression on transitional B cells which increases to higher surface expression on mature and memory B-cells with innate-like features (at protein level) (PubMed:23857366). Expressed a low levels in naive and germinal center B-cells but also expressed in NK cells (at protein level). Expressed in a population of thymically derived natrurally ocurring regulatory T-cells that exhibits a memory phenotype, specialized in suppressing immune response to self-antigens (PubMed:20190142). Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. {ECO:0000269|PubMed:11493702, ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:15838509, ECO:0000269|PubMed:16849395, ECO:0000269|PubMed:20190142, ECO:0000269|PubMed:23857366}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7522061 rs12041673 rs944627 rs2282284 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16849395, ECO:0000269|PubMed:20190142}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |