| Gene Information | |
|---|---|
| Gene Name | POP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 360 |
| Protein Names | Blood vessel epicardial substance (hBVES) (Popeye domain-containing protein 1) (Popeye protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000104356 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NE79 |
| Gene Card | BVES |
| Uniprot ID | Q8NE79 |
| Pfam | PF04831 |
| In ASD | no |
| Allosteric Prediction | no (-0.916311467) |
| Ortholog in Animals | Alpaca_ POP1 ( ortholog_one2one ) Dog_ POP1 ( ortholog_one2one ) GuineaPig_ POP1 ( ortholog_one2one ) Macaque_ POP1 ( ortholog_one2one ) Mouse_ Pop1 ( ortholog_one2one ) Pig_ POP1 ( ortholog_one2one ) Rat_ Pop1 ( ortholog_one2one ) Rabbit_ POP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SERAC1 |
| Tissue | NA |
| Tissue Specificity | Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle. {ECO:0000269|PubMed:10441744, ECO:0000269|PubMed:10882522, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:26642364}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9486039 rs2275289 rs869025337 |
| Subcellular location [CC] | Lateral cell membrane {ECO:0000269|PubMed:16188940}. Cell junction, tight junction {ECO:0000269|PubMed:16188940}. Membrane {ECO:0000269|PubMed:26642364}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000269|PubMed:26642364}. Membrane, caveola {ECO:0000250|UniProtKB:Q9ES83}. Note=Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells. {ECO:0000250|UniProtKB:Q9ES83}. |
| Mouse PG classification | NA |
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