| Gene Information | |
|---|---|
| Gene Name | CCR7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 378 |
| Protein Names | C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000126353 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P32248 |
| Gene Card | CCR7 |
| Uniprot ID | P32248 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.169647297) |
| Ortholog in Animals | Alpaca_ CCR7 ( ortholog_one2one ) Dog_ CCR7 ( ortholog_one2one ) GuineaPig_ CCR7 ( ortholog_one2one ) Macaque_ CCR7 ( ortholog_one2one ) Mouse_ Ccr7 ( ortholog_one2one ) Pig_ CCR7 ( ortholog_one2one ) Rat_ Ccr7 ( ortholog_one2one ) Rabbit_ CCR7 ( ortholog_one2one ) |
| Ohnologs | CCR2, CXCR4, CCR1, CX3CR1, CCR9, CCR8, CCR3 |
| Paralogs | CCR10, ACKR4, CCR9, CXCR6, CCR6, GALR2, XCR1, RGR, ACKR3, CCRL2, CCR8, CCR1, ACKR2, CCR4, CX3CR1, CCR2, CCR5, CCR3, CXCR5, CXCR4, CXCR1, CXCR2, CXCR3 |
| Tissue | lymph.node, spleen, whole.blood |
| Tissue Specificity | Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6QZH (X-ray 2.10A ) |
| DBSNP | rs2228015 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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