| Gene Information | |
|---|---|
| Gene Name | POP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 89 |
| Protein Names | Pyrin domain-containing protein 1 (PAAD-only protein 1) (Pyrin-only protein 1) (cellular POP1) (cPOP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000104356 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WXC3 |
| Gene Card | PYDC1 |
| Uniprot ID | Q8WXC3 |
| Pfam | PF02758 |
| In ASD | no |
| Allosteric Prediction | no (-0.916311467) |
| Ortholog in Animals | Alpaca_ POP1 ( ortholog_one2one ) Dog_ POP1 ( ortholog_one2one ) GuineaPig_ POP1 ( ortholog_one2one ) Macaque_ POP1 ( ortholog_one2one ) Mouse_ Pop1 ( ortholog_one2one ) Pig_ POP1 ( ortholog_one2one ) Rat_ Pop1 ( ortholog_one2one ) Rabbit_ POP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SERAC1 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in monocytes, macrophages and granulocytes. {ECO:0000269|PubMed:12656673}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2HM2 (NMR - ) 4QOB (X-ray 2.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12656673}. Note=Recruited to specks formed by PYCARD within the cytoplasm. {ECO:0000269|PubMed:17178784}. |
| Mouse PG classification | NA |
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