| Gene Information | |
|---|---|
| Gene Name | POMC |
| Organism | Homo sapiens (Human) |
| Gene Length | 267 |
| Protein Names | Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin] |
| Target Name | pro-opiomelanocortin |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000115138 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01189 |
| Gene Card | POMC |
| Uniprot ID | P01189 |
| Pfam | PF00976; PF08384; PF08035 |
| In ASD | no |
| Allosteric Prediction | yes (1.182168626) |
| Ortholog in Animals | Alpaca_ POMC ( ortholog_one2one ) Dog_ POMC ( ortholog_one2one ) GuineaPig_ POMC ( ortholog_one2one ) Macaque_ POMC ( ortholog_one2one ) Mouse_ Pomc ( ortholog_one2one ) Rat_ Pomc ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | pituitary.gland |
| Tissue Specificity | ACTH and MSH are produced by the pituitary gland. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4XNH (X-ray 2.10A ) 4XPD (X-ray 2.81A ) 4Y49 (X-ray 3.95A ) 6TUB (NMR - ) 7F53 (EM 3.00A ) 7F54 (EM 3.00A ) 7PIV (EM 2.86A ) |
| DBSNP | rs139750421 rs28932471 rs750136455 rs8192606 rs80326661 rs28932472 |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:P01193}. Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. {ECO:0000250|UniProtKB:P01193}. |
| Mouse PG classification | HPG |
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