| Gene Information | |
|---|---|
| Gene Name | TRMT10A |
| Organism | Homo sapiens (Human) |
| Gene Length | 339 |
| Protein Names | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000145331 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TBZ6 |
| Gene Card | TRMT10A |
| Uniprot ID | Q8TBZ6 |
| Pfam | PF01746 |
| In ASD | no |
| Allosteric Prediction | no (-1.577110839) |
| Ortholog in Animals | Alpaca_ TRMT10A ( ortholog_one2one ) Dog_ TRMT10A ( ortholog_one2one ) GuineaPig_ TRMT10A ( ortholog_one2one ) Macaque_ TRMT10A ( ortholog_one2one ) Mouse_ Trmt10a ( ortholog_one2one ) Pig_ TRMT10A ( ortholog_one2one ) Rat_ Trmt10a ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRMT10C, TRMT10B |
| Tissue | NA |
| Tissue Specificity | Expressed in embryonic and fetal brain. It is expressed throughout the dorsal telencephalon at 8 and 11 weeks of gestation, with highest expression in ventricular zone and marginal zone. Detected in cerebellar cortex and nuclei, but not in dorsal telencephalon, at later stages. {ECO:0000269|PubMed:24204302}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4FMW (X-ray 2.00A ) |
| DBSNP | rs10007569 rs587777744 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:24204302}. Nucleus, nucleolus {ECO:0000269|PubMed:24204302}. |
| Mouse PG classification | NA |
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