| Gene Information | |
|---|---|
| Gene Name | ARAP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1544 |
| Protein Names | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000120318 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8WWN8 |
| Gene Card | ARAP3 |
| Uniprot ID | Q8WWN8 |
| Pfam | PF01412; PF00169; PF00788; PF00620; PF07647 |
| In ASD | no |
| Allosteric Prediction | no (-0.726501158) |
| Ortholog in Animals | Alpaca_ ARAP3 ( ortholog_one2one ) Dog_ ARAP3 ( ortholog_one2one ) GuineaPig_ ARAP3 ( ortholog_one2one ) Macaque_ ARAP3 ( ortholog_one2one ) Mouse_ Arap3 ( ortholog_one2one ) Pig_ ARAP3 ( ortholog_one2one ) Rat_ Arap3 ( ortholog_one2one ) Rabbit_ ARAP3 ( ortholog_one2one ) |
| Ohnologs | ARAP1, ARAP2 |
| Paralogs | ASAP2, ASAP1, ACAP3, ARAP2, GIT1, AGFG1, ADAP1, SMAP1, AGAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, ARAP1, AGFG2, APPL2, ARFGAP3, GIT2, ADAP2, SMAP2, AGAP2, ACAP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KG5 (NMR - ) 2LNW (NMR - ) 5JCP (X-ray 2.10A ) 5JD0 (X-ray 2.30A ) 7A9B (X-ray 2.00A ) |
| DBSNP | rs1031904 rs1562420371 rs61749636 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}. |
| Mouse PG classification | NA |
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