| Gene Information | |
|---|---|
| Gene Name | SH2D4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 454 |
| Protein Names | SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000104611 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9H788 |
| Gene Card | SH2D4A |
| Uniprot ID | Q9H788 |
| Pfam | PF00017 |
| In ASD | no |
| Allosteric Prediction | no (-1.018141534) |
| Ortholog in Animals | Alpaca_ SH2D4A ( ortholog_one2one ) Dog_ SH2D4A ( ortholog_one2one ) GuineaPig_ SH2D4A ( ortholog_one2one ) Macaque_ SH2D4A ( ortholog_one2one ) Mouse_ Sh2d4a ( ortholog_one2one ) Rat_ Sh2d4a ( ortholog_one2one ) Rabbit_ SH2D4A ( ortholog_one2one ) |
| Ohnologs | SH2D4B |
| Paralogs | SH2D2A, HSH2D, SH2D7, SH2D4B |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Aberrantly expressed in some cancers. {ECO:0000269|PubMed:12476414}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35647122 rs4921637 rs877386 rs34608771 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18641339}. Note=Located at podocyte foot processes. {ECO:0000250}. |
| Mouse PG classification | NA |
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