| Gene Information | |
|---|---|
| Gene Name | POLR2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1174 |
| Protein Names | DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000047315 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P30876 |
| Gene Card | POLR2B |
| Uniprot ID | P30876 |
| Pfam | PF04563; PF04561; PF04565; PF04566; PF04567; PF00562; PF04560 |
| In ASD | no |
| Allosteric Prediction | yes (0.415374282) |
| Ortholog in Animals | Alpaca_ POLR2B ( ortholog_one2one ) Dog_ POLR2B ( ortholog_one2one ) GuineaPig_ POLR2B ( ortholog_one2one ) Macaque_ POLR2B ( ortholog_one2one ) Mouse_ Polr2b ( ortholog_one2one ) Pig_ POLR2B ( ortholog_one2one ) Rat_ Polr2b ( ortholog_one2one ) Rabbit_ POLR2B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | POLR3B, POLR1B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.599016(Rat);0.253316(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5IY6 (EM 7.20A ) 5IY7 (EM 8.60A ) 5IY8 (EM 7.90A ) 5IY9 (EM 6.30A ) 5IYA (EM 5.40A ) 5IYB (EM 3.90A ) 5IYC (EM 3.90A ) 5IYD (EM 3.90A ) 6DRD (EM 3.90A ) 6O9L (EM 7.20A ) 6XRE (EM 4.60A ) 7LBM (EM 4.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:9852112}. |
| Mouse PG classification | NA |
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