| Gene Information | |
|---|---|
| Gene Name | POLR2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1970 |
| Protein Names | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000181222 ) 3 ( ENSG00000284832 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P24928 |
| Gene Card | POLR2A |
| Uniprot ID | P24928 |
| Pfam | PF04997; PF00623; PF04983; PF05000; PF04998; PF04992; PF04990; PF05001 |
| In ASD | no |
| Allosteric Prediction | yes (0.635292669) |
| Ortholog in Animals | Alpaca_ POLR2A ( ortholog_one2one ) Dog_ POLR2A ( ortholog_one2one ) GuineaPig_ POLR2A ( ortholog_one2one ) Macaque_ POLR2A ( ortholog_one2one ) Mouse_ Polr2a ( ortholog_one2one ) Pig_ POLR2A ( ortholog_one2one ) Rat_ Polr2a ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | POLR3A, POLR1A |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2GHQ (X-ray 2.05A ) 2GHT (X-ray 1.80A ) 2LTO (NMR - ) 3D9K (X-ray 2.20A ) 3D9L (X-ray 2.20A ) 3D9M (X-ray 1.75A ) 3D9N (X-ray 1.60A ) 3D9O (X-ray 2.00A ) 3D9P (X-ray 2.10A ) 4JXT (X-ray 1.90A ) 5IY6 (EM 7.20A ) 5IY7 (EM 8.60A ) 5IY8 (EM 7.90A ) 5IY9 (EM 6.30A ) 5IYA (EM 5.40A ) 5IYB (EM 3.90A ) 5IYC (EM 3.90A ) 5IYD (EM 3.90A ) 5M3H (X-ray 2.50A ) 5M3J (X-ray 3.50A ) 6DRD (EM 3.90A ) 6F5P (X-ray 4.14A ) 6G0R (X-ray 1.25A ) 6IC8 (X-ray 1.93A ) 6IC9 (X-ray 1.75A ) 6O9L (EM 7.20A ) 6Q5Y (X-ray 2.85A ) 6XKB (X-ray 1.60A ) 6XRE (EM 4.60A ) 7EGB (EM 3.30A ) 7EGC (EM 3.90A ) 7LBM (EM 4.80A ) |
| DBSNP | rs2229198 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:26566685, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9852112}. Cytoplasm {ECO:0000269|PubMed:26566685}. Chromosome {ECO:0000269|PubMed:28076779}. Note=Hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear (PubMed:26566685). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (PubMed:28076779). {ECO:0000269|PubMed:26566685, ECO:0000269|PubMed:28076779}. |
| Mouse PG classification | NA |
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