| Gene Information | |
|---|---|
| Gene Name | KRS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 491 |
| Protein Names | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13188 |
| Gene Card | STK3 |
| Uniprot ID | Q13188 |
| Pfam | PF11629; PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues. {ECO:0000269|PubMed:8566796}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.071031(Mouse);0.010507(Rat);0.097525(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3WWS (X-ray 2.01A ) 4HKD (X-ray 1.50A ) 4L0N (X-ray 1.40A ) 4LG4 (X-ray 2.42A ) 4LGD (X-ray 3.05A ) 4OH9 (X-ray 1.70A ) 5BRM (X-ray 2.65A ) 5DH3 (X-ray 2.47A ) 6AO5 (X-ray 2.96A ) 6AR2 (X-ray 1.55A ) 8A66 (X-ray 1.90A ) |
| DBSNP | rs36047674 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21145499}. Nucleus {ECO:0000269|PubMed:21145499}. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (PubMed:19525978, PubMed:11278283). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation (PubMed:19525978). {ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:19525978}. |
| Mouse PG classification | NA |
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