| Gene Information | |
|---|---|
| Gene Name | RHOT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 618 |
| Protein Names | Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000140983 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IXI1 |
| Gene Card | RHOT2 |
| Uniprot ID | Q8IXI1 |
| Pfam | PF08355; PF08356; PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.30572105) |
| Ortholog in Animals | Alpaca_ RHOT2 ( ortholog_one2one ) Macaque_ RHOT2 ( ortholog_one2one ) Mouse_ Rhot2 ( ortholog_one2one ) Pig_ RHOT2 ( ortholog_one2one ) Rat_ Rhot2 ( ortholog_one2one ) |
| Ohnologs | RHOT1 |
| Paralogs | RND1, CDC42, RHOT1, RHOBTB3, RAC1, RAC3, RHOJ, RHOA, RHOC, RHOB, RHOV, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RHOU, RAC2, RHOBTB1, RHOH |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:15218247}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5KUT (X-ray 1.69A ) |
| DBSNP | rs1139897 rs3177338 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria. |
| Mouse PG classification | NA |
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