| Gene Information | |
|---|---|
| Gene Name | POLK |
| Organism | Homo sapiens (Human) |
| Gene Length | 870 |
| Protein Names | DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) |
| Target Name | dna polymerase kappa |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000122008 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9UBT6 |
| Gene Card | POLK |
| Uniprot ID | Q9UBT6 |
| Pfam | PF00817; PF11799; PF11798 |
| In ASD | no |
| Allosteric Prediction | no (-0.140429126) |
| Ortholog in Animals | Alpaca_ POLK ( ortholog_one2one ) Dog_ POLK ( ortholog_one2one ) GuineaPig_ POLK ( ortholog_one2one ) Macaque_ POLK ( ortholog_one2one ) Mouse_ Polk ( ortholog_one2one ) Pig_ POLK ( ortholog_one2one ) Rat_ Polk ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | REV1, POLI, ESCO1, POLH, ESCO2 |
| Tissue | NA |
| Tissue Specificity | Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. {ECO:0000269|PubMed:10518552, ECO:0000269|PubMed:10620008}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1T94 (X-ray 2.40A ) 2LSI (NMR - ) 2OH2 (X-ray 3.05A ) 2W7O (X-ray 3.16A ) 2W7P (X-ray 3.71A ) 3IN5 (X-ray 3.20A ) 3PZP (X-ray 3.34A ) 4BA9 (X-ray 2.73A ) 4GK5 (X-ray 3.21A ) 4U6P (X-ray 2.59A ) 4U7C (X-ray 2.80A ) 5T14 (X-ray 3.00A ) 5W2A (X-ray 2.90A ) 5W2C (X-ray 2.50A ) 6BRX (X-ray 2.80A ) 6BS1 (X-ray 3.15A ) 6CST (X-ray 2.00A ) 7NV0 (EM 3.40A ) 7NV1 (EM 6.40A ) |
| DBSNP | rs35257416 rs5744713 rs3822587 rs35501530 rs5744716 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12414988, ECO:0000269|PubMed:28297716}. Note=Detected throughout the nucleus and at replication foci (PubMed:12414988). Recruited to DNA damage sites in response to ultraviolet irradiation: N6-methyladenosine (m6A)-containing mRNAs accumulate in the vicinity of DNA damage sites and their presence is required to recruit POLK (PubMed:28297716). {ECO:0000269|PubMed:12414988, ECO:0000269|PubMed:28297716}. |
| Mouse PG classification | NA |
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