| Gene Information | |
|---|---|
| Gene Name | RARB |
| Organism | Homo sapiens (Human) |
| Gene Length | 455 |
| Protein Names | Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon) |
| Target Name | retinoic acid receptor beta |
| Target Type | Successful target |
| Gene Age | 810 ( ENSG00000077092 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P10826 |
| Gene Card | RARB |
| Uniprot ID | P10826 |
| Pfam | PF00104; PF00105 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000043393) |
| Ortholog in Animals | Alpaca_ RARB ( ortholog_one2one ) Dog_ RARB ( ortholog_one2one ) GuineaPig_ RARB ( ortholog_one2one ) Macaque_ RARB ( ortholog_one2one ) Mouse_ Rarb ( ortholog_one2one ) Pig_ RARB ( ortholog_one2one ) Rat_ Rarb ( ortholog_one2one ) Rabbit_ RARB ( ortholog_one2one ) |
| Ohnologs | PPARD, RARA, RARG, PPARA |
| Paralogs | NR1H4, VDR, RARG, NR1D2, RARA, PPARD, NR1H2, RORC, THRB, NR1D1, NR1H3, NR1I2, PPARG, NR1I3, RORB, PPARA, RORA, THRA |
| Tissue | NA |
| Tissue Specificity | Expressed in aortic endothelial cells (at protein level). {ECO:0000269|PubMed:28167758}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HRA (NMR - ) 1XAP (X-ray 2.10A ) 4DM6 (X-ray 1.90A ) 4DM8 (X-ray 2.30A ) 4JYG (X-ray 2.35A ) 4JYH (X-ray 2.60A ) 4JYI (X-ray 1.90A ) 5UAN (X-ray 3.51A ) 6SSQ (X-ray 2.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:28167758}.; [Isoform Beta-1]: Nucleus.; [Isoform Beta-2]: Nucleus.; [Isoform Beta-4]: Cytoplasm. |
| Mouse PG classification | NA |
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