| Gene Information | |
|---|---|
| Gene Name | POLE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 527 |
| Protein Names | DNA polymerase epsilon subunit 2 (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) |
| Target Name | dna polymerase epsilon subunit 2 |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000100479 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P56282 |
| Gene Card | POLE2 |
| Uniprot ID | P56282 |
| Pfam | PF04042; PF12213 |
| In ASD | no |
| Allosteric Prediction | yes (0.042191811) |
| Ortholog in Animals | Alpaca_ POLE2 ( ortholog_one2one ) Alpaca_ POLE2 ( ortholog_one2many ) Dog_ POLE2 ( ortholog_one2one ) GuineaPig_ POLE2 ( ortholog_one2one ) Macaque_ POLE2 ( ortholog_one2one ) Mouse_ Pole2 ( ortholog_one2one ) Pig_ POLE2 ( ortholog_one2one ) Rat_ Pole2 ( ortholog_one2one ) Rabbit_ POLE2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | colon, substantia.nigra |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005434(Rat);0.082759(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2V6Z (NMR - ) 5VBN (X-ray 2.35A ) 7PFO (EM 3.20A ) 7PLO (EM 2.80A ) |
| DBSNP | rs34857719 rs34574266 rs45515094 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | NA |
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