| Gene Information | |
|---|---|
| Gene Name | POLD |
| Organism | Homo sapiens (Human) |
| Gene Length | 1107 |
| Protein Names | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P28340 |
| Gene Card | POLD1 |
| Uniprot ID | P28340 |
| Pfam | PF00136; PF03104; PF14260 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with high levels of expression in heart and lung. {ECO:0000269|PubMed:23770608}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003049(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6S1M (EM 4.27A ) 6S1N (EM 4.86A ) 6S1O (EM 8.10A ) 6TNY (EM 3.08A ) 6TNZ (EM 4.05A ) |
| DBSNP | rs9282830 rs3218773 rs9282831 rs3218772 rs1726801 rs1726803 rs3218750 rs2230243 rs587777627 rs397514632 rs199783227 rs771700024 rs3218775 rs765437818 rs3219457 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:22801543}. Note=Colocalizes with PCNA and POLD3 at S phase replication sites (PubMed:11595739). After UV irradiation, recruited to DNA damage sites within 2 hours, independently on the cell cycle phase, nor on PCNA ubiquitination. This recruitment requires POLD3, PCNA and RFC1-replication factor C complex (PubMed:20227374, PubMed:22801543). {ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:22801543}. |
| Mouse PG classification | NA |
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