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Gene Information
Gene Name
POLB
Organism
Homo sapiens (Human)
Gene Length
335
Protein Names
DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-)
Target Name
dna polymerase beta
Target Type
Clinical trial target
Gene Age
1714 ( ENSG00000070501 )
Evolutionary Stage
Cellular_organisms
AlphaFoldDB
P06746
Gene Card
POLB
Uniprot ID
P06746
Pfam
PF14792; PF14791; PF10391; PF14716
In ASD
yes
Allosteric Prediction
yes (1.000203908)
Ortholog in Animals
Alpaca_ POLB ( ortholog_one2one )
Dog_ POLB ( ortholog_one2one )
GuineaPig_ POLB ( ortholog_one2one )
Macaque_ POLB ( ortholog_one2one )
Mouse_ Polb ( ortholog_one2one )
Pig_ POLB ( ortholog_one2one )
Rat_ Polb ( ortholog_one2one )
Rabbit_ POLB ( ortholog_one2one )
Ohnologs
POLL
Paralogs
DNTT, POLM, POLL
Tissue
NA
Tissue Specificity
NA
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1BPX
(X-ray
2.40A
)
1BPY
(X-ray
2.20A
)
1BPZ
(X-ray
2.60A
)
1MQ2
(X-ray
3.10A
)
1MQ3
(X-ray
2.80A
)
1TV9
(X-ray
2.00A
)
1TVA
(X-ray
2.60A
)
1ZJM
(X-ray
2.10A
)
1ZJN
(X-ray
2.61A
)
1ZQA
(X-ray
3.20A
)
1ZQB
(X-ray
3.20A
)
1ZQC
(X-ray
3.20A
)
1ZQD
(X-ray
3.50A
)
1ZQE
(X-ray
3.70A
)
1ZQF
(X-ray
2.90A
)
1ZQG
(X-ray
3.10A
)
1ZQH
(X-ray
3.10A
)
1ZQI
(X-ray
2.70A
)
1ZQJ
(X-ray
3.30A
)
1ZQK
(X-ray
3.20A
)
1ZQL
(X-ray
3.30A
)
1ZQM
(X-ray
3.20A
)
1ZQN
(X-ray
3.00A
)
1ZQO
(X-ray
3.20A
)
1ZQP
(X-ray
2.80A
)
1ZQQ
(X-ray
3.30A
)
1ZQR
(X-ray
3.70A
)
1ZQS
(X-ray
3.30A
)
1ZQT
(X-ray
3.40A
)
2FMP
(X-ray
1.65A
)
2FMQ
(X-ray
2.20A
)
2FMS
(X-ray
2.00A
)
2I9G
(X-ray
2.10A
)
2ISO
(X-ray
2.10A
)
2ISP
(X-ray
2.20A
)
2P66
(X-ray
2.50A
)
2PXI
(X-ray
2.10A
)
3C2K
(X-ray
2.40A
)
3C2L
(X-ray
2.60A
)
3C2M
(X-ray
2.15A
)
3GDX
(X-ray
2.20A
)
3ISB
(X-ray
2.00A
)
3ISC
(X-ray
2.00A
)
3ISD
(X-ray
2.60A
)
3JPN
(X-ray
2.15A
)
3JPO
(X-ray
2.00A
)
3JPP
(X-ray
2.10A
)
3JPQ
(X-ray
1.90A
)
3JPR
(X-ray
2.10A
)
3JPS
(X-ray
2.00A
)
3JPT
(X-ray
2.15A
)
3LK9
(X-ray
2.50A
)
3MBY
(X-ray
2.00A
)
3OGU
(X-ray
1.84A
)
3RH4
(X-ray
1.92A
)
3RH5
(X-ray
2.10A
)
3RH6
(X-ray
2.05A
)
3RJE
(X-ray
2.10A
)
3RJF
(X-ray
2.30A
)
3RJG
(X-ray
2.00A
)
3RJH
(X-ray
2.20A
)
3RJI
(X-ray
2.30A
)
3RJJ
(X-ray
2.00A
)
3RJK
(X-ray
2.10A
)
3TFR
(X-ray
2.00A
)
3TFS
(X-ray
2.00A
)
4DO9
(X-ray
2.05A
)
4DOA
(X-ray
2.05A
)
4DOB
(X-ray
2.05A
)
4DOC
(X-ray
1.95A
)
4F5N
(X-ray
1.80A
)
4F5O
(X-ray
2.00A
)
4F5P
(X-ray
1.85A
)
4F5Q
(X-ray
2.25A
)
4F5R
(X-ray
2.20A
)
4GXI
(X-ray
1.95A
)
4GXJ
(X-ray
2.20A
)
4GXK
(X-ray
2.00A
)
4JWM
(X-ray
2.00A
)
4JWN
(X-ray
2.39A
)
4KLD
(X-ray
1.92A
)
4KLE
(X-ray
1.97A
)
4KLF
(X-ray
1.85A
)
4KLG
(X-ray
1.70A
)
4KLH
(X-ray
1.88A
)
4KLI
(X-ray
1.60A
)
4KLJ
(X-ray
1.80A
)
4KLL
(X-ray
1.84A
)
4KLM
(X-ray
1.75A
)
4KLO
(X-ray
1.84A
)
4KLQ
(X-ray
2.00A
)
4KLS
(X-ray
1.98A
)
4KLT
(X-ray
1.98A
)
4KLU
(X-ray
1.97A
)
4LVS
(X-ray
2.00A
)
4M2Y
(X-ray
2.27A
)
4M47
(X-ray
2.37A
)
4M9G
(X-ray
2.01A
)
4M9H
(X-ray
2.39A
)
4M9J
(X-ray
2.04A
)
4M9L
(X-ray
2.09A
)
4M9N
(X-ray
2.28A
)
4MF2
(X-ray
2.40A
)
4MF8
(X-ray
2.32A
)
4MFA
(X-ray
2.27A
)
4MFC
(X-ray
2.13A
)
4MFF
(X-ray
2.55A
)
4NLK
(X-ray
2.49A
)
4NLN
(X-ray
2.26A
)
4NLZ
(X-ray
2.68A
)
4NM1
(X-ray
2.42A
)
4NM2
(X-ray
2.52A
)
4NXZ
(X-ray
2.56A
)
4NY8
(X-ray
2.25A
)
4O5C
(X-ray
2.36A
)
4O5E
(X-ray
2.53A
)
4O5K
(X-ray
2.06A
)
4O9M
(X-ray
2.30A
)
4P2H
(X-ray
1.99A
)
4PGQ
(X-ray
2.30A
)
4PGX
(X-ray
2.08A
)
4PGY
(X-ray
2.26A
)
4PH5
(X-ray
2.55A
)
4PHA
(X-ray
2.52A
)
4PHD
(X-ray
2.21A
)
4PHE
(X-ray
2.15A
)
4PHP
(X-ray
2.60A
)
4PPX
(X-ray
2.08A
)
4R63
(X-ray
1.85A
)
4R64
(X-ray
2.20A
)
4R65
(X-ray
1.95A
)
4R66
(X-ray
2.25A
)
4RPX
(X-ray
1.90A
)
4RPY
(X-ray
1.90A
)
4RPZ
(X-ray
2.19A
)
4RQ0
(X-ray
2.20A
)
4RQ1
(X-ray
2.70A
)
4RQ2
(X-ray
2.20A
)
4RQ3
(X-ray
2.00A
)
4RQ4
(X-ray
2.10A
)
4RQ5
(X-ray
2.32A
)
4RQ6
(X-ray
2.25A
)
4RQ7
(X-ray
2.00A
)
4RQ8
(X-ray
2.00A
)
4RT2
(X-ray
1.92A
)
4RT3
(X-ray
1.92A
)
4TUP
(X-ray
1.80A
)
4TUQ
(X-ray
2.37A
)
4TUR
(X-ray
2.17A
)
4TUS
(X-ray
2.42A
)
4UAW
(X-ray
1.90A
)
4UAY
(X-ray
1.98A
)
4UAZ
(X-ray
1.88A
)
4UB1
(X-ray
2.34A
)
4UB2
(X-ray
2.51A
)
4UB3
(X-ray
2.06A
)
4UB4
(X-ray
1.95A
)
4UB5
(X-ray
2.15A
)
4UBB
(X-ray
1.90A
)
4UBC
(X-ray
2.00A
)
4YMM
(X-ray
2.20A
)
4YMN
(X-ray
2.59A
)
4YMO
(X-ray
2.15A
)
4YN4
(X-ray
2.24A
)
4Z6C
(X-ray
2.68A
)
4Z6D
(X-ray
2.51A
)
4Z6E
(X-ray
2.75A
)
4Z6F
(X-ray
2.44A
)
5BOL
(X-ray
1.98A
)
5BOM
(X-ray
2.00A
)
5BPC
(X-ray
2.00A
)
5DB6
(X-ray
2.83A
)
5DB7
(X-ray
2.21A
)
5DB8
(X-ray
2.55A
)
5DB9
(X-ray
2.45A
)
5DBA
(X-ray
1.97A
)
5DBB
(X-ray
2.25A
)
5DBC
(X-ray
2.40A
)
5EOZ
(X-ray
2.09A
)
5HHH
(X-ray
2.36A
)
5HHI
(X-ray
2.52A
)
5J0O
(X-ray
2.00A
)
5J0P
(X-ray
2.20A
)
5J0Q
(X-ray
2.00A
)
5J0R
(X-ray
2.00A
)
5J0S
(X-ray
2.00A
)
5J0T
(X-ray
2.00A
)
5J0U
(X-ray
2.10A
)
5J0W
(X-ray
2.40A
)
5J0X
(X-ray
2.00A
)
5J0Y
(X-ray
2.00A
)
5J29
(X-ray
2.20A
)
5J2A
(X-ray
2.50A
)
5J2B
(X-ray
2.50A
)
5J2C
(X-ray
2.10A
)
5J2D
(X-ray
2.10A
)
5J2E
(X-ray
2.10A
)
5J2F
(X-ray
2.10A
)
5J2G
(X-ray
2.10A
)
5J2H
(X-ray
2.30A
)
5J2I
(X-ray
2.40A
)
5J2J
(X-ray
2.20A
)
5J2K
(X-ray
2.10A
)
5TB8
(X-ray
2.00A
)
5TB9
(X-ray
2.49A
)
5TBA
(X-ray
2.49A
)
5TBB
(X-ray
2.39A
)
5TBC
(X-ray
1.85A
)
5TZV
(X-ray
2.00A
)
5U2R
(X-ray
1.80A
)
5U2S
(X-ray
2.30A
)
5U2T
(X-ray
1.79A
)
5U8G
(X-ray
2.17A
)
5U8H
(X-ray
2.15A
)
5U8I
(X-ray
2.45A
)
5U9H
(X-ray
1.85A
)
5UGN
(X-ray
2.00A
)
5UGO
(X-ray
1.90A
)
5UGP
(X-ray
1.96A
)
5V1F
(X-ray
2.18A
)
5V1G
(X-ray
1.80A
)
5V1H
(X-ray
1.95A
)
5V1I
(X-ray
2.04A
)
5V1J
(X-ray
2.62A
)
5V1N
(X-ray
2.00A
)
5V1O
(X-ray
1.80A
)
5V1P
(X-ray
1.99A
)
5V1R
(X-ray
2.08A
)
5VEZ
(X-ray
2.04A
)
5VRW
(X-ray
2.58A
)
5VRX
(X-ray
2.20A
)
5VRY
(X-ray
1.90A
)
5VRZ
(X-ray
2.05A
)
5VS0
(X-ray
2.10A
)
5VS1
(X-ray
2.50A
)
5VS2
(X-ray
2.33A
)
5VS3
(X-ray
1.70A
)
5VS4
(X-ray
1.87A
)
5WNX
(X-ray
2.55A
)
5WNY
(X-ray
2.10A
)
5WNZ
(X-ray
2.20A
)
5WO0
(X-ray
1.60A
)
6BEL
(X-ray
1.90A
)
6BEM
(X-ray
1.88A
)
6BTE
(X-ray
2.20A
)
6BTF
(X-ray
1.75A
)
6CLY
(X-ray
2.19A
)
6CPQ
(X-ray
1.93A
)
6CR3
(X-ray
1.95A
)
6CR4
(X-ray
1.80A
)
6CR5
(X-ray
1.98A
)
6CR6
(X-ray
2.10A
)
6CR7
(X-ray
2.29A
)
6CR8
(X-ray
2.05A
)
6CR9
(X-ray
1.96A
)
6CRB
(X-ray
2.15A
)
6CRC
(X-ray
2.30A
)
6CRH
(X-ray
2.33A
)
6CTI
(X-ray
2.00A
)
6CTJ
(X-ray
2.10A
)
6CTK
(X-ray
2.15A
)
6CTL
(X-ray
2.00A
)
6CTM
(X-ray
2.10A
)
6CTN
(X-ray
1.92A
)
6CTO
(X-ray
2.04A
)
6CTP
(X-ray
2.20A
)
6CTQ
(X-ray
1.87A
)
6CTR
(X-ray
1.85A
)
6CTT
(X-ray
2.00A
)
6CTU
(X-ray
1.90A
)
6CTV
(X-ray
2.02A
)
6CTW
(X-ray
1.98A
)
6CTX
(X-ray
2.02A
)
6CU9
(X-ray
2.04A
)
6CUA
(X-ray
2.17A
)
6CUB
(X-ray
2.05A
)
6DIA
(X-ray
1.97A
)
6DIC
(X-ray
1.99A
)
6E3R
(X-ray
2.26A
)
6E3V
(X-ray
1.96A
)
6E3W
(X-ray
2.02A
)
6E3X
(X-ray
2.65A
)
6G2Q
(X-ray
2.15A
)
6MR7
(X-ray
2.14A
)
6MR8
(X-ray
1.90A
)
6N2R
(X-ray
2.10A
)
6N2S
(X-ray
2.46A
)
6N2T
(X-ray
2.60A
)
6NKR
(X-ray
2.45A
)
6NKS
(X-ray
2.35A
)
6NKT
(X-ray
2.60A
)
6NKU
(X-ray
1.90A
)
6NKV
(X-ray
1.85A
)
6NKW
(X-ray
1.98A
)
6NKX
(X-ray
1.98A
)
6NKY
(X-ray
2.09A
)
6NKZ
(X-ray
2.01A
)
6NL0
(X-ray
1.97A
)
6PH5
(X-ray
2.60A
)
6PH6
(X-ray
2.60A
)
6PKZ
(X-ray
2.74A
)
6U2O
(X-ray
2.30A
)
6U6B
(X-ray
3.11A
)
6UOK
(X-ray
2.55A
)
6UOL
(X-ray
1.94A
)
6UOM
(X-ray
2.05A
)
6W2M
(X-ray
2.00A
)
7ICE
(X-ray
2.80A
)
7ICF
(X-ray
3.10A
)
7ICG
(X-ray
3.00A
)
7ICH
(X-ray
2.90A
)
7ICI
(X-ray
2.80A
)
7ICJ
(X-ray
3.50A
)
7ICK
(X-ray
2.90A
)
7ICL
(X-ray
3.10A
)
7ICM
(X-ray
3.00A
)
7ICN
(X-ray
2.80A
)
7ICO
(X-ray
3.30A
)
7ICP
(X-ray
3.00A
)
7ICQ
(X-ray
2.90A
)
7ICR
(X-ray
3.00A
)
7ICS
(X-ray
2.80A
)
7ICT
(X-ray
2.80A
)
7ICU
(X-ray
3.30A
)
7ICV
(X-ray
2.80A
)
7K96
(X-ray
2.10A
)
7K97
(X-ray
2.40A
)
7MZ0
(X-ray
2.02A
)
7MZ1
(X-ray
2.17A
)
7MZ2
(X-ray
2.09A
)
7MZ3
(X-ray
2.42A
)
7MZ4
(X-ray
2.08A
)
7MZ8
(X-ray
2.60A
)
7RBE
(X-ray
1.89A
)
7RBF
(X-ray
1.84A
)
7RBG
(X-ray
1.90A
)
7RBH
(X-ray
1.75A
)
7RBI
(X-ray
1.93A
)
7RBJ
(X-ray
1.91A
)
7RBK
(X-ray
2.20A
)
7RBL
(X-ray
1.98A
)
7RBM
(X-ray
2.21A
)
7RBN
(X-ray
2.90A
)
7RBO
(X-ray
2.96A
)
7S9J
(X-ray
1.91A
)
7S9K
(X-ray
1.97A
)
7S9L
(X-ray
2.05A
)
7S9M
(X-ray
2.31A
)
7S9N
(X-ray
1.71A
)
7S9O
(X-ray
2.23A
)
7S9P
(X-ray
1.86A
)
7S9Q
(X-ray
1.90A
)
8ICA
(X-ray
3.00A
)
8ICB
(X-ray
3.10A
)
8ICC
(X-ray
2.80A
)
8ICE
(X-ray
3.20A
)
8ICF
(X-ray
2.90A
)
8ICG
(X-ray
3.30A
)
8ICH
(X-ray
3.30A
)
8ICI
(X-ray
2.80A
)
8ICJ
(X-ray
3.20A
)
8ICK
(X-ray
2.70A
)
8ICL
(X-ray
3.10A
)
8ICM
(X-ray
2.90A
)
8ICN
(X-ray
2.80A
)
8ICO
(X-ray
2.70A
)
8ICP
(X-ray
2.90A
)
8ICQ
(X-ray
3.00A
)
8ICR
(X-ray
2.90A
)
8ICS
(X-ray
2.90A
)
8ICT
(X-ray
3.10A
)
8ICU
(X-ray
3.00A
)
8ICV
(X-ray
3.20A
)
8ICW
(X-ray
3.30A
)
8ICX
(X-ray
3.00A
)
8ICY
(X-ray
3.10A
)
8ICZ
(X-ray
3.10A
)
9ICA
(X-ray
3.00A
)
9ICB
(X-ray
3.20A
)
9ICC
(X-ray
3.10A
)
9ICE
(X-ray
3.30A
)
9ICF
(X-ray
3.00A
)
9ICG
(X-ray
3.00A
)
9ICH
(X-ray
2.90A
)
9ICI
(X-ray
3.10A
)
9ICJ
(X-ray
3.10A
)
9ICK
(X-ray
2.70A
)
9ICL
(X-ray
2.80A
)
9ICM
(X-ray
2.90A
)
9ICN
(X-ray
3.00A
)
9ICO
(X-ray
2.90A
)
9ICP
(X-ray
3.10A
)
9ICQ
(X-ray
2.90A
)
9ICR
(X-ray
3.00A
)
9ICS
(X-ray
2.90A
)
9ICT
(X-ray
3.00A
)
9ICU
(X-ray
2.90A
)
9ICV
(X-ray
2.70A
)
9ICW
(X-ray
2.60A
)
9ICX
(X-ray
2.60A
)
9ICY
(X-ray
3.00A
)
DBSNP
rs3136797
Subcellular location [CC]
Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
Mouse PG classification
NA
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