| Gene Information | |
|---|---|
| Gene Name | MTCL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1905 |
| Protein Names | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000168502 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y4B5 |
| Gene Card | MTCL1 |
| Uniprot ID | Q9Y4B5 |
| Pfam | PF14818; PF11365 |
| In ASD | no |
| Allosteric Prediction | no (-0.554396982) |
| Ortholog in Animals | Alpaca_ MTCL1 ( ortholog_one2one ) Dog_ MTCL1 ( ortholog_one2one ) GuineaPig_ MTCL1 ( ortholog_one2one ) Macaque_ MTCL1 ( ortholog_one2one ) Mouse_ Mtcl1 ( ortholog_one2one ) Pig_ MTCL1 ( ortholog_one2one ) Rat_ Mtcl1 ( ortholog_one2one ) Rabbit_ MTCL1 ( ortholog_one2one ) |
| Ohnologs | SOGA1, SOGA3 |
| Paralogs | SOGA3, SOGA1 |
| Tissue | cerebellar.hemisphere, cerebellum |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35739383 rs1965665 rs3744979 rs12386117 rs11874468 |
| Subcellular location [CC] | Lateral cell membrane {ECO:0000250}. Apical cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23902687}. Midbody {ECO:0000269|PubMed:23902687}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23902687}. Note=Colocalized with microtubules at the base of cilia. Gradually accumulates on the apicobasal microtubule bundles during epithelial cell polarization (By similarity). Colocalized with the apicobasal microtubule bundles running beneath the lateral membrane. Colocalized with microtubule bundles in the spindle pole in mitotic cells and in the midbodies at the end of cytokinesis. {ECO:0000250}. |
| Mouse PG classification | NA |
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