Gene Information
Gene NamePNPT1
OrganismHomo sapiens (Human)
Gene Length783
Protein NamesPolyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000138035 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ8TCS8
Gene CardPNPT1
Uniprot IDQ8TCS8
PfamPF00013; PF03726; PF01138; PF03725
In ASDno
Allosteric Predictionno (-0.37563373)
Ortholog in AnimalsAlpaca_ PNPT1 ( ortholog_one2one )
Dog_ PNPT1 ( ortholog_one2one )
GuineaPig_ PNPT1 ( ortholog_one2one )
Macaque_ PNPT1 ( ortholog_one2one )
Mouse_ Pnpt1 ( ortholog_one2one )
Pig_ PNPT1 ( ortholog_one2one )
Rat_ Pnpt1 ( ortholog_one2one )
Rabbit_ PNPT1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001899(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3U1K  (X-ray  2.13A  5ZF6  (X-ray  2.80A 
DBSNP rs782572  rs34928857  rs397514598  rs397514599  rs7594497 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:16055741}. Mitochondrion matrix {ECO:0000269|PubMed:12798676, ECO:0000269|PubMed:16055741}. Mitochondrion intermembrane space {ECO:0000269|PubMed:16966381};
Peripheral membrane protein {ECO:0000269|PubMed:16966381}.
Mouse PG classificationLPG
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