Gene Information | |
---|---|
Gene Name | PNPT1 |
Organism | Homo sapiens (Human) |
Gene Length | 783 |
Protein Names | Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein) |
Target Name | NA |
Target Type | NA |
Gene Age | 1488 ( ENSG00000138035 ) |
Evolutionary Stage | Euk+Bac |
AlphaFoldDB | Q8TCS8 |
Gene Card | PNPT1 |
Uniprot ID | Q8TCS8 |
Pfam | PF00013; PF03726; PF01138; PF03725 |
In ASD | no |
Allosteric Prediction | no (-0.37563373) |
Ortholog in Animals | Alpaca_ PNPT1 ( ortholog_one2one ) Dog_ PNPT1 ( ortholog_one2one ) GuineaPig_ PNPT1 ( ortholog_one2one ) Macaque_ PNPT1 ( ortholog_one2one ) Mouse_ Pnpt1 ( ortholog_one2one ) Pig_ PNPT1 ( ortholog_one2one ) Rat_ Pnpt1 ( ortholog_one2one ) Rabbit_ PNPT1 ( ortholog_one2one ) |
Ohnologs | NA |
Paralogs | NA |
Tissue | NA |
Tissue Specificity | NA |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);NULL(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 3U1K (X-ray 2.13A ) 5ZF6 (X-ray 2.80A ) |
DBSNP | rs782572 rs34928857 rs397514598 rs397514599 rs7594497 |
Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16055741}. Mitochondrion matrix {ECO:0000269|PubMed:12798676, ECO:0000269|PubMed:16055741}. Mitochondrion intermembrane space {ECO:0000269|PubMed:16966381}; Peripheral membrane protein {ECO:0000269|PubMed:16966381}. |
Mouse PG classification | LPG |
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