| Gene Information | |
|---|---|
| Gene Name | PNPLA6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1375 |
| Protein Names | Patatin-like phospholipase domain-containing protein 6 (EC 3.1.1.5) (Neuropathy target esterase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000032444 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8IY17 |
| Gene Card | PNPLA6 |
| Uniprot ID | Q8IY17 |
| Pfam | PF00027; PF01734 |
| In ASD | no |
| Allosteric Prediction | yes (0.092296371) |
| Ortholog in Animals | Alpaca_ PNPLA6 ( ortholog_one2one ) Dog_ PNPLA6 ( ortholog_one2one ) GuineaPig_ PNPLA6 ( ortholog_one2one ) Macaque_ PNPLA6 ( ortholog_one2one ) Mouse_ Pnpla6 ( ortholog_one2one ) Pig_ PNPLA6 ( ortholog_one2one ) Rat_ Pnpla6 ( ortholog_one2one ) Rabbit_ PNPLA6 ( ortholog_one2one ) |
| Ohnologs | PNPLA7 |
| Paralogs | PNPLA7 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain. {ECO:0000269|PubMed:25480986, ECO:0000269|PubMed:9576844}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs587777184 rs17854645 rs587777615 rs587777185 rs121434416 rs17854647 rs541098659 rs587777181 rs121434415 rs587777183 rs786201037 rs754429587 rs587777182 rs748506175 rs773955314 rs587777854 rs1555751592 rs142422525 rs1211079280 rs374434303 rs1204274988 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044461}; Single-pass type III membrane protein {ECO:0000269|PubMed:15044461}. |
| Mouse PG classification | LPG |
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