| Gene Information | |
|---|---|
| Gene Name | PNP |
| Organism | Homo sapiens (Human) |
| Gene Length | 289 |
| Protein Names | Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) |
| Target Name | purine nucleoside phosphorylase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000198805 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P00491 |
| Gene Card | PNP |
| Uniprot ID | P00491 |
| Pfam | PF01048 |
| In ASD | no |
| Allosteric Prediction | yes (0.571315092) |
| Ortholog in Animals | Alpaca_ PNP ( ortholog_one2one ) Dog_ PNP ( ortholog_one2one ) GuineaPig_ PNP ( ortholog_one2one ) Mouse_ Pnp ( ortholog_one2many ) Mouse_ Pnp2 ( ortholog_one2many ) Pig_ PNP ( ortholog_one2one ) Rat_ Pnp ( ortholog_one2one ) Rabbit_ PNP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MTAP |
| Tissue | NA |
| Tissue Specificity | Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology. {ECO:0000269|PubMed:22509282}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1M73 (X-ray 2.30A ) 1PF7 (X-ray 2.60A ) 1PWY (X-ray 2.80A ) 1RCT (X-ray 2.80A ) 1RFG (X-ray 2.90A ) 1RR6 (X-ray 2.50A ) 1RSZ (X-ray 2.20A ) 1RT9 (X-ray 2.30A ) 1ULA (X-ray 2.75A ) 1ULB (X-ray 2.75A ) 1V2H (X-ray 2.70A ) 1V3Q (X-ray 2.80A ) 1V41 (X-ray 2.85A ) 1V45 (X-ray 2.86A ) 1YRY (X-ray 2.80A ) 2A0W (X-ray 2.28A ) 2A0X (X-ray 2.28A ) 2A0Y (X-ray 2.28A ) 2OC4 (X-ray 2.59A ) 2OC9 (X-ray 2.59A ) 2ON6 (X-ray 2.50A ) 2Q7O (X-ray 2.90A ) 3BGS (X-ray 2.10A ) 3D1V (X-ray 2.70A ) 3GB9 (X-ray 2.30A ) 3GGS (X-ray 2.52A ) 3INY (X-ray 2.75A ) 3K8O (X-ray 2.40A ) 3K8Q (X-ray 2.50A ) 3PHB (X-ray 2.30A ) 4EAR (X-ray 1.70A ) 4EB8 (X-ray 2.30A ) 4ECE (X-ray 2.60A ) 4GKA (X-ray 2.20A ) 5ETJ (X-ray 2.30A ) 5UGF (X-ray 2.20A ) |
| DBSNP | rs1049564 rs104894453 rs104894450 rs104894454 rs104894452 rs104894451 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:22509282}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |