| Gene Information | |
|---|---|
| Gene Name | PNN |
| Organism | Homo sapiens (Human) |
| Gene Length | 717 |
| Protein Names | Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000100941 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H307 |
| Gene Card | PNN |
| Uniprot ID | Q9H307 |
| Pfam | PF04696; PF04697 |
| In ASD | no |
| Allosteric Prediction | no (-0.692636087) |
| Ortholog in Animals | Alpaca_ PNN ( ortholog_one2one ) Dog_ PNN ( ortholog_one2one ) GuineaPig_ PNN ( ortholog_one2one ) Macaque_ PNN ( ortholog_one2one ) Mouse_ Pnn ( ortholog_one2one ) Pig_ PNN ( ortholog_one2one ) Rat_ Pnn ( ortholog_one2one ) Rabbit_ PNN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | substantia.nigra |
| Tissue Specificity | Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. {ECO:0000269|PubMed:10095061, ECO:0000269|PubMed:8922384, ECO:0000269|PubMed:9447706}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001268(Rat);0.017143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs13021 |
| Subcellular location [CC] | Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein. |
| Mouse PG classification | NA |
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