| Gene Information | |
|---|---|
| Gene Name | PNMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 282 |
| Protein Names | Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) |
| Target Name | phenylethanolamine n-methyltransferase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000141744 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P11086 |
| Gene Card | PNMT |
| Uniprot ID | P11086 |
| Pfam | PF01234 |
| In ASD | no |
| Allosteric Prediction | yes (0.399281217) |
| Ortholog in Animals | Alpaca_ PNMT ( ortholog_one2one ) GuineaPig_ PNMT ( ortholog_one2one ) Macaque_ PNMT ( ortholog_one2one ) Mouse_ Pnmt ( ortholog_one2one ) Pig_ PNMT ( ortholog_one2one ) Rat_ Pnmt ( ortholog_one2one ) Rabbit_ PNMT ( ortholog_one2one ) |
| Ohnologs | NNMT |
| Paralogs | INMT, NNMT |
| Tissue | adrenal.gland |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HNN (X-ray 2.40A ) 1N7I (X-ray 2.80A ) 1N7J (X-ray 2.70A ) 1YZ3 (X-ray 2.40A ) 2AN3 (X-ray 2.20A ) 2AN4 (X-ray 2.20A ) 2AN5 (X-ray 2.50A ) 2G70 (X-ray 2.40A ) 2G71 (X-ray 2.20A ) 2G72 (X-ray 2.00A ) 2G8N (X-ray 2.15A ) 2OBF (X-ray 2.30A ) 2ONY (X-ray 2.60A ) 2ONZ (X-ray 2.80A ) 2OPB (X-ray 2.80A ) 3HCA (X-ray 2.40A ) 3HCB (X-ray 2.40A ) 3HCC (X-ray 2.30A ) 3HCD (X-ray 2.39A ) 3HCE (X-ray 2.85A ) 3HCF (X-ray 2.70A ) 3KPJ (X-ray 2.50A ) 3KPU (X-ray 2.40A ) 3KPV (X-ray 2.40A ) 3KPW (X-ray 2.40A ) 3KPY (X-ray 2.40A ) 3KQM (X-ray 2.40A ) 3KQO (X-ray 2.40A ) 3KQP (X-ray 2.40A ) 3KQQ (X-ray 2.50A ) 3KQS (X-ray 2.00A ) 3KQT (X-ray 2.40A ) 3KQV (X-ray 2.30A ) 3KQW (X-ray 2.49A ) 3KQY (X-ray 2.20A ) 3KR0 (X-ray 2.60A ) 3KR1 (X-ray 2.30A ) 3KR2 (X-ray 2.30A ) 4DM3 (X-ray 2.40A ) 4MIK (X-ray 1.95A ) 4MQ4 (X-ray 2.20A ) 6WS1 (X-ray 2.76A ) |
| DBSNP | rs11569781 rs36060376 rs34530498 rs34341496 rs5639 rs5640 rs5641 rs5642 rs5643 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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