| Gene Information | |
|---|---|
| Gene Name | PNKP |
| Organism | Homo sapiens (Human) |
| Gene Length | 521 |
| Protein Names | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000039650 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96T60 |
| Gene Card | PNKP |
| Uniprot ID | Q96T60 |
| Pfam | PF17913; PF08645 |
| In ASD | no |
| Allosteric Prediction | no (-0.061468777) |
| Ortholog in Animals | Alpaca_ PNKP ( ortholog_one2one ) Dog_ PNKP ( ortholog_one2one ) GuineaPig_ PNKP ( ortholog_one2one ) Macaque_ PNKP ( ortholog_one2one ) Mouse_ Pnkp ( ortholog_one2one ) Pig_ PNKP ( ortholog_one2one ) Rat_ Pnkp ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193). {ECO:0000269|PubMed:10446192, ECO:0000269|PubMed:10446193}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2BRF (X-ray 1.40A ) 2W3O (X-ray 1.85A ) |
| DBSNP | rs3739168 rs3739173 rs267606957 rs3739185 rs3739186 rs267606956 rs786203983 rs376854895 rs3739206 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10446193}. Chromosome {ECO:0000269|PubMed:28453785}. Note=Localizes to site of double-strand breaks. {ECO:0000269|PubMed:28453785}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |