| Gene Information | |
|---|---|
| Gene Name | RFC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 591 |
| Protein Names | Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000035928 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P41440 |
| Gene Card | SLC19A1 |
| Uniprot ID | P41440 |
| Pfam | PF01770 |
| In ASD | no |
| Allosteric Prediction | yes (0.458288026) |
| Ortholog in Animals | Alpaca_ RFC1 ( ortholog_one2one ) Dog_ RFC1 ( ortholog_one2one ) GuineaPig_ RFC1 ( ortholog_one2one ) Macaque_ RFC1 ( ortholog_one2one ) Mouse_ Rfc1 ( ortholog_one2one ) Pig_ RFC1 ( ortholog_one2one ) Rat_ Rfc1 ( ortholog_one2one ) Rabbit_ RFC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Placenta, liver, and to a much smaller extent, in lung. {ECO:0000269|PubMed:7826387}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1051266 rs757838708 rs35786590 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10347183, ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:9767079}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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