| Gene Information | |
|---|---|
| Gene Name | PRPF8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2335 |
| Protein Names | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000174231 ) 3 ( ENSG00000274442 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6P2Q9 |
| Gene Card | PRPF8 |
| Uniprot ID | Q6P2Q9 |
| Pfam | PF01398; PF08082; PF08083; PF08084; PF12134; PF10598; PF10597; PF10596 |
| In ASD | no |
| Allosteric Prediction | no (-0.155183098) |
| Ortholog in Animals | Alpaca_ PRPF8 ( ortholog_one2one ) Dog_ PRPF8 ( ortholog_one2one ) GuineaPig_ PRPF8 ( ortholog_one2one ) Macaque_ PRPF8 ( ortholog_one2one ) Mouse_ Prpf8 ( ortholog_one2one ) Pig_ PRPF8 ( ortholog_one2one ) Rat_ Prpf8 ( ortholog_one2one ) Rabbit_ PRPF8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10411133}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.197329(Rat);0.140432(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3E9L (X-ray 1.95A ) 3ENB (X-ray 1.85A ) 3JCR (EM 7.00A ) 3LRU (X-ray 1.85A ) 4JK7 (X-ray 1.40A ) 4JK8 (X-ray 1.15A ) 4JK9 (X-ray 1.50A ) 4JKA (X-ray 1.32A ) 4JKB (X-ray 1.30A ) 4JKC (X-ray 1.50A ) 4JKD (X-ray 1.55A ) 4JKE (X-ray 1.65A ) 4JKF (X-ray 1.95A ) 4JKG (X-ray 1.80A ) 4JKH (X-ray 1.80A ) 4KIT (X-ray 3.60A ) 5MQF (EM 5.90A ) 5O9Z (EM 4.50A ) 5XJC (EM 3.60A ) 5YZG (EM 4.10A ) 5Z56 (EM 5.10A ) 5Z57 (EM 6.50A ) 5Z58 (EM 4.90A ) 6AH0 (EM 5.70A ) 6AHD (EM 3.80A ) 6FF4 (EM 16.00A ) 6FF7 (EM 4.50A ) 6ICZ (EM 3.00A ) 6ID0 (EM 2.90A ) 6ID1 (EM 2.86A ) 6QDV (EM 3.30A ) 6QW6 (EM 2.92A ) 6QX9 (EM 3.28A ) 6S8Q (X-ray 2.39A ) 6S9I (X-ray 2.60A ) 6ZYM (EM 3.40A ) 7A5P (EM 5.00A ) 7AAV (EM 4.20A ) 7ABF (EM 3.90A ) 7ABG (EM 7.80A ) 7ABI (EM 8.00A ) 7BDI (X-ray 2.80A ) 7BDJ (X-ray 2.59A ) 7BDK (X-ray 2.52A ) 7BDL (X-ray 2.69A ) 7DVQ (EM 2.89A ) 7OS2 (EM 2.76A ) 7PX3 (EM 3.05A ) 7W59 (EM 3.60A ) 7W5A (EM 3.60A ) 7W5B (EM 4.30A ) |
| DBSNP | rs1043391 rs11559304 rs1043396 rs1043399 rs121434239 rs121434240 rs121434236 rs121434236 rs121434238 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:30728453}. Nucleus speckle {ECO:0000305}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |