Gene Information
Gene NamePLSCR1
OrganismHomo sapiens (Human)
Gene Length318
Protein NamesPhospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000188313 )
Evolutionary StageEukaryota
AlphaFoldDBO15162
Gene CardPLSCR1
Uniprot IDO15162
PfamPF03803
In ASDno
Allosteric Predictionno (-0.403223632)
Ortholog in AnimalsAlpaca_ PLSCR1 ( ortholog_one2one )
Dog_ PLSCR1 ( ortholog_one2one )
Mouse_ Plscr2 ( ortholog_one2many )
Mouse_ 1700057G04Rik ( ortholog_one2many )
Mouse_ Plscr1 ( ortholog_one2many )
Pig_ PLSCR1 ( ortholog_one2one )
Rat_ Plscr2 ( ortholog_one2many )
Rat_ 1700057G04Rik ( ortholog_one2many )
OhnologsPLSCR3
ParalogsPLSCR4, PLSCR5, PLSCR3, PLSCR2
TissueNA
Tissue SpecificityExpressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle. {ECO:0000269|PubMed:10930526, ECO:0000269|PubMed:9218461}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1Y2A  (X-ray  2.20A  ) 
DBSNP rs343320 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12564925, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23590222, ECO:0000269|PubMed:24648509, ECO:0000269|PubMed:26745724};
Single-pass type II membrane protein {ECO:0000269|PubMed:26745724}. Cell membrane {ECO:0000269|PubMed:12564925};
Lipid-anchor {ECO:0000305|PubMed:12564925};
Cytoplasmic side. Nucleus {ECO:0000269|PubMed:12564925, ECO:0000269|PubMed:16091359, ECO:0000269|PubMed:24648509}. Cytoplasm {ECO:0000269|PubMed:22052202}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:26745724}. Note=Localizes to the perinuclear region in the presence of RELT (PubMed:22052202). Palmitoylation regulates its localization to the cell membrane or the nucleus;
trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus (PubMed:12564925). {ECO:0000269|PubMed:12564925, ECO:0000269|PubMed:22052202}.
Mouse PG classificationNA
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