| Gene Information | |
|---|---|
| Gene Name | PMCH |
| Organism | Homo sapiens (Human) |
| Gene Length | 165 |
| Protein Names | Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid (NGE) (Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI) (Neuropeptide E-I); Melanin-concentrating hormone (MCH)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000183395 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P20382 |
| Gene Card | PMCH |
| Uniprot ID | P20382 |
| Pfam | PF05824 |
| In ASD | no |
| Allosteric Prediction | yes (0.428514239) |
| Ortholog in Animals | Alpaca_ PMCH ( ortholog_one2one ) Dog_ PMCH ( ortholog_one2one ) GuineaPig_ PMCH ( ortholog_one2one ) Macaque_ PMCH ( ortholog_one2one ) Mouse_ Pmch ( ortholog_one2one ) Pig_ PMCH ( ortholog_one2one ) Rat_ Pmch ( ortholog_one2one ) Rabbit_ PMCH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. {ECO:0000269|PubMed:9191099}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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