| Gene Information | |
|---|---|
| Gene Name | PMAT |
| Organism | Homo sapiens (Human) |
| Gene Length | 530 |
| Protein Names | Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (Solute carrier family 29 member 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q7RTT9 |
| Gene Card | SLC29A4 |
| Uniprot ID | Q7RTT9 |
| Pfam | PF01733 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed abundantly in the heart, in both cardiomyocytes and vascular endothelial cells (at protein level). Highly expressed in brain, kidney and skeletal muscle. In the brain expressed in cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes putamen and in the spinal cord. Lower expression in liver, pancreas, and liver. Expressed in endometrial tissue, exclusively in the stroma. Expression is high in the proliferative phase, decreases during the secretory phase, and is no longer detectable in the menstrual phase. {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:17393420}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17854505 rs17855675 rs17857336 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells. {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718}. |
| Mouse PG classification | NA |
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