| Gene Information | |
|---|---|
| Gene Name | EXOI |
| Organism | Homo sapiens (Human) |
| Gene Length | 846 |
| Protein Names | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UQ84 |
| Gene Card | EXO1 |
| Uniprot ID | Q9UQ84 |
| Pfam | PF00867; PF00752 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. {ECO:0000269|PubMed:10856833, ECO:0000269|PubMed:9685493, ECO:0000269|PubMed:9788596, ECO:0000269|PubMed:9823303}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.096335(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3QE9 (X-ray 2.51A ) 3QEA (X-ray 3.10A ) 3QEB (X-ray 3.00A ) 5UZV (X-ray 2.45A ) 5V04 (X-ray 2.65A ) 5V05 (X-ray 2.90A ) 5V06 (X-ray 2.75A ) 5V07 (X-ray 2.15A ) 5V08 (X-ray 2.81A ) 5V09 (X-ray 2.75A ) 5V0A (X-ray 2.38A ) 5V0B (X-ray 2.63A ) 5V0C (X-ray 2.58A ) 5V0D (X-ray 2.63A ) 5V0E (X-ray 2.74A ) |
| DBSNP | rs1472620416 rs4149864 rs4149865 rs143546023 rs147663824 rs4149909 rs4149910 rs735943 rs571928768 rs4149962 rs4149963 rs4149964 rs4149965 rs4149966 rs4149967 rs1047840 rs12122770 rs4149978 rs61736331 rs61736331 rs1776148 rs1635498 rs9350 rs4150001 rs200622305 rs145975455 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11429708, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:17426132}. Note=Colocalizes with PCNA to discrete nuclear foci in S-phase. |
| Mouse PG classification | NA |
| click here to return to the previous page | |