| Gene Information | |
|---|---|
| Gene Name | PLXND1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1925 |
| Protein Names | Plexin-D1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000004399 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y4D7 |
| Gene Card | PLXND1 |
| Uniprot ID | Q9Y4D7 |
| Pfam | PF08337; PF20170; PF01437; PF01403; PF01833; PF17960 |
| In ASD | no |
| Allosteric Prediction | no (-1.167404346) |
| Ortholog in Animals | Alpaca_ PLXND1 ( ortholog_one2one ) Dog_ PLXND1 ( ortholog_one2one ) GuineaPig_ PLXND1 ( ortholog_one2one ) Macaque_ PLXND1 ( ortholog_one2one ) Mouse_ Plxnd1 ( ortholog_one2one ) Pig_ PLXND1 ( ortholog_one2one ) Rat_ Plxnd1 ( ortholog_one2one ) Rabbit_ PLXND1 ( ortholog_one2one ) |
| Ohnologs | PLXNA3, PLXNB1, PLXNB3, PLXNA4, PLXNA2 |
| Paralogs | PLXNA3, PLXNA2, PLXNA1, PLXNA4, PLXNB2, PLXNC1, PLXNB3, PLXNB1 |
| Tissue | NA |
| Tissue Specificity | Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes. {ECO:0000269|PubMed:12412018}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3H6N (X-ray 2.00A ) |
| DBSNP | rs2285372 rs2255703 rs2625962 rs2625973 rs2713625 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q3UH93}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q3UH93}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:24841563}. |
| Mouse PG classification | NA |
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