| Gene Information | |
|---|---|
| Gene Name | PLXDC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 500 |
| Protein Names | Plexin domain-containing protein 1 (Tumor endothelial marker 3) (Tumor endothelial marker 7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000161381 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8IUK5 |
| Gene Card | PLXDC1 |
| Uniprot ID | Q8IUK5 |
| Pfam | PF01437 |
| In ASD | no |
| Allosteric Prediction | no (-1.165650334) |
| Ortholog in Animals | Alpaca_ PLXDC1 ( ortholog_one2one ) Dog_ PLXDC1 ( ortholog_one2one ) GuineaPig_ PLXDC1 ( ortholog_one2one ) Macaque_ PLXDC1 ( ortholog_one2one ) Mouse_ Plxdc1 ( ortholog_one2one ) Pig_ PLXDC1 ( ortholog_one2one ) Rat_ Plxdc1 ( ortholog_one2one ) Rabbit_ PLXDC1 ( ortholog_one2one ) |
| Ohnologs | PLXDC2 |
| Paralogs | PLXDC2 |
| Tissue | NA |
| Tissue Specificity | Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. {ECO:0000269|PubMed:10947988, ECO:0000269|PubMed:11559528, ECO:0000269|PubMed:17560052, ECO:0000269|PubMed:18316703}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs75117355 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.; [Isoform 2]: Secreted {ECO:0000305}.; [Isoform 3]: Secreted {ECO:0000305}.; [Isoform 4]: Cytoplasm {ECO:0000305}. |
| Mouse PG classification | NA |
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