Gene Information
Gene NameAARS2
OrganismHomo sapiens (Human)
Gene Length985
Protein NamesAlanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)
Target Namealanine--trna ligase, mitochondrial
Target TypeNA
Gene Age987 ( ENSG00000124608 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ5JTZ9
Gene CardAARS2
Uniprot IDQ5JTZ9
PfamPF01411; PF07973
In ASDno
Allosteric Predictionno (-0.177041856)
Ortholog in AnimalsAlpaca_ AARS2 ( ortholog_one2one )
Dog_ AARS2 ( ortholog_one2one )
GuineaPig_ AARS2 ( ortholog_one2one )
Macaque_ AARS2 ( ortholog_one2one )
Mouse_ Aars2 ( ortholog_one2one )
Pig_ AARS2 ( ortholog_one2one )
Rat_ Aars2 ( ortholog_one2one )
Rabbit_ AARS2 ( ortholog_one2one )
OhnologsNA
ParalogsAARS1, AARSD1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6NLQ  (X-ray  1.15A  6NLY  (X-ray  2.31A  6NOW  (X-ray  4.10A 
DBSNP rs587777590  rs375949891  rs387907061  rs200105202  rs324136  rs587777592  rs495294  rs138119149  rs35623954  rs35783144  rs543267101 
Subcellular location [CC]Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:21549344}.
Mouse PG classificationLPG
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