| Gene Information | |
|---|---|
| Gene Name | PLU1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1544 |
| Protein Names | Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UGL1 |
| Gene Card | KDM5B |
| Uniprot ID | Q9UGL1 |
| Pfam | PF01388; PF02373; PF02375; PF00628; PF08429; PF02928 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). {ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:10616211, ECO:0000269|PubMed:10878660, ECO:0000269|PubMed:12237901, ECO:0000269|PubMed:15803180}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MA5 (NMR - ) 2MNY (NMR - ) 2MNZ (NMR - ) 5A1F (X-ray 2.10A ) 5A3N (X-ray 2.00A ) 5A3P (X-ray 2.01A ) 5A3T (X-ray 1.90A ) 5A3W (X-ray 2.00A ) 5FPL (X-ray 2.35A ) 5FPU (X-ray 2.24A ) 5FUN (X-ray 2.30A ) 5FUP (X-ray 2.15A ) 5FV3 (X-ray 2.37A ) 5FY4 (X-ray 2.10A ) 5FY5 (X-ray 2.47A ) 5FY9 (X-ray 2.03A ) 5FYB (X-ray 1.87A ) 5FYS (X-ray 1.89A ) 5FYT (X-ray 1.87A ) 5FYU (X-ray 2.06A ) 5FYV (X-ray 1.87A ) 5FYY (X-ray 2.18A ) 5FYZ (X-ray 1.75A ) 5FZ0 (X-ray 2.42A ) 5FZ1 (X-ray 2.39A ) 5FZ3 (X-ray 2.50A ) 5FZ4 (X-ray 2.07A ) 5FZ6 (X-ray 2.33A ) 5FZ7 (X-ray 2.30A ) 5FZ8 (X-ray 1.86A ) 5FZ9 (X-ray 2.06A ) 5FZA (X-ray 2.10A ) 5FZB (X-ray 2.18A ) 5FZC (X-ray 2.05A ) 5FZD (X-ray 2.05A ) 5FZE (X-ray 2.02A ) 5FZF (X-ray 1.97A ) 5FZG (X-ray 1.96A ) 5FZH (X-ray 2.09A ) 5FZI (X-ray 1.95A ) 5FZK (X-ray 2.05A ) 5FZL (X-ray 2.55A ) 5FZM (X-ray 2.49A ) 5LW9 (X-ray 2.30A ) 5LWB (X-ray 2.39A ) 6EIN (X-ray 2.11A ) 6EIU (X-ray 1.88A ) 6EIY (X-ray 2.15A ) 6EJ0 (X-ray 2.06A ) 6EJ1 (X-ray 2.07A ) 6EK6 (X-ray 2.05A ) 6H4Z (X-ray 2.30A ) 6H50 (X-ray 2.19A ) 6H51 (X-ray 2.21A ) 6H52 (X-ray 2.14A ) 6RBI (X-ray 2.21A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:12237901}. |
| Mouse PG classification | NA |
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