| Gene Information | |
|---|---|
| Gene Name | PLTP |
| Organism | Homo sapiens (Human) |
| Gene Length | 493 |
| Protein Names | Phospholipid transfer protein (Lipid transfer protein II) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000100979 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P55058 |
| Gene Card | PLTP |
| Uniprot ID | P55058 |
| Pfam | PF01273; PF02886 |
| In ASD | no |
| Allosteric Prediction | no (-0.32588495) |
| Ortholog in Animals | Alpaca_ PLTP ( ortholog_one2one ) Dog_ PLTP ( ortholog_one2one ) GuineaPig_ PLTP ( ortholog_one2one ) Macaque_ PLTP ( ortholog_one2one ) Mouse_ Pltp ( ortholog_one2one ) Rat_ Pltp ( ortholog_one2one ) Rabbit_ PLTP ( ortholog_one2one ) |
| Ohnologs | BPIFC |
| Paralogs | BPI, LBP, BPIFC, CETP, BPIFB2, BPIFB6, BPIFB4, BPIFB3, BPIFA2, BPIFA1, BPIFA3, BPIFB1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highest level of expression in the ovary, thymus and placenta, with moderate levels found in the pancreas, small intestine, testis, lung and prostrate. Low level expression in the kidney, liver and spleen, with very low levels found in the heart, colon, skeletal muscle, leukocytes and brain. Expressed in the cortical neurons. {ECO:0000269|PubMed:19321130, ECO:0000269|PubMed:7654777}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11569636 rs56126980 rs144710772 rs6065903 rs11569675 rs1804161 rs1056929 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:19321130}. Nucleus {ECO:0000269|PubMed:19321130}. Note=Nuclear export is XPO1/CRM1-dependent. {ECO:0000269|PubMed:19321130}. |
| Mouse PG classification | NA |
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