| Gene Information | |
|---|---|
| Gene Name | GPR139 |
| Organism | Homo sapiens (Human) |
| Gene Length | 353 |
| Protein Names | Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) (G-protein-coupled receptor PGR3) |
| Target Name | g-protein-coupled receptor pgr3 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000180269 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6DWJ6 |
| Gene Card | GPR139 |
| Uniprot ID | Q6DWJ6 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.467240969) |
| Ortholog in Animals | Alpaca_ GPR139 ( ortholog_one2one ) Dog_ GPR139 ( ortholog_one2one ) GuineaPig_ GPR139 ( ortholog_one2one ) Macaque_ GPR139 ( ortholog_one2one ) Mouse_ Gpr139 ( ortholog_one2one ) Pig_ GPR139 ( ortholog_one2one ) Rat_ Gpr139 ( ortholog_one2one ) Rabbit_ GPR139 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GPR142 |
| Tissue | NA |
| Tissue Specificity | Expressed almost exclusively in the brain. Detected at very low levels in the peripheral tissues. {ECO:0000269|PubMed:15845401}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7VUG (EM 3.20A ) 7VUH (EM 3.22A ) 7VUI (EM 3.30A ) 7VUJ (EM 3.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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