| Gene Information | |
|---|---|
| Gene Name | NRCAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 1304 |
| Protein Names | Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000091129 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q92823 |
| Gene Card | NRCAM |
| Uniprot ID | Q92823 |
| Pfam | PF13882; PF00041; PF07679 |
| In ASD | no |
| Allosteric Prediction | yes (0.351412256) |
| Ortholog in Animals | Alpaca_ NRCAM ( ortholog_one2one ) Dog_ NRCAM ( ortholog_one2one ) GuineaPig_ NRCAM ( ortholog_one2one ) Macaque_ NRCAM ( ortholog_one2one ) Mouse_ Nrcam ( ortholog_one2one ) Pig_ NRCAM ( ortholog_one2one ) Rat_ Nrcam ( ortholog_one2one ) Rabbit_ NRCAM ( ortholog_one2one ) |
| Ohnologs | L1CAM, CHL1, NFASC |
| Paralogs | CNTN5, CNTN2, NFASC, ROBO2, SDK1, SDK2, CNTN3, HMCN2, CNTN6, DSCAML1, VSIG10L, CNTN1, IGDCC4, IGSF21, VCAM1, ROBO1, L1CAM, BOC, DCC, IGDCC3, ROBO4, IGSF9, VSIG10, DSCAM, CDON, NCAM1, ROBO3, CHL1, NEO1, IGSF9B, MXRA5, IGSF10, PTPRQ, NCAM2, PRTG, CNTN4 |
| Tissue | adrenal.gland, cerebral.cortex |
| Tissue Specificity | Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1UEN (NMR - ) 1UEY (NMR - ) |
| DBSNP | rs6958498 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q810U4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q810U4}. Cell projection, axon {ECO:0000250|UniProtKB:Q810U4}. Secreted {ECO:0000250|UniProtKB:Q810U4}. Note=Detected at nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}. |
| Mouse PG classification | NA |
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