| Gene Information | |
|---|---|
| Gene Name | PLK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 646 |
| Protein Names | Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase) |
| Target Name | serine/threonine-protein kinase plk3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000173846 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9H4B4 |
| Gene Card | PLK3 |
| Uniprot ID | Q9H4B4 |
| Pfam | PF00069; PF00659 |
| In ASD | no |
| Allosteric Prediction | yes (0.233508392) |
| Ortholog in Animals | Alpaca_ PLK3 ( ortholog_one2one ) Dog_ PLK3 ( ortholog_one2one ) GuineaPig_ PLK3 ( ortholog_one2one ) Macaque_ PLK3 ( ortholog_one2one ) Mouse_ Plk3 ( ortholog_one2one ) Pig_ PLK3 ( ortholog_one2one ) Rat_ Plk3 ( ortholog_one2one ) Rabbit_ PLK3 ( ortholog_one2one ) |
| Ohnologs | PLK2 |
| Paralogs | PLK1, PLK5, PLK2, PLK4 |
| Tissue | NA |
| Tissue Specificity | Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001490(Rat);0.009091(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4B6L (X-ray 1.90A ) |
| DBSNP | rs17884581 rs17884316 rs17880471 rs17884653 rs17855444 rs17880829 rs17881786 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line-specific expression or post-translational modifications. {ECO:0000269|PubMed:17264206}. |
| Mouse PG classification | NA |
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