| Gene Information | |
|---|---|
| Gene Name | PLK |
| Organism | Homo sapiens (Human) |
| Gene Length | 603 |
| Protein Names | Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P53350 |
| Gene Card | PLK1 |
| Uniprot ID | P53350 |
| Pfam | PF00069; PF00659 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Placenta and colon. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002133(Rat);0.023684(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1Q4K (X-ray 2.30A ) 1Q4O (X-ray 2.20A ) 1UMW (X-ray 1.90A ) 2OGQ (X-ray 1.95A ) 2OJX (X-ray 2.85A ) 2OU7 (X-ray 2.40A ) 2OWB (X-ray 2.10A ) 2RKU (X-ray 1.95A ) 2V5Q (X-ray 2.30A ) 2YAC (X-ray 2.20A ) 3BZI (X-ray 2.10A ) 3C5L (X-ray 2.33A ) 3FC2 (X-ray 2.45A ) 3FVH (X-ray 1.58A ) 3HIH (X-ray 1.70A ) 3HIK (X-ray 1.77A ) 3KB7 (X-ray 2.50A ) 3P2W (X-ray 1.66A ) 3P2Z (X-ray 1.79A ) 3P34 (X-ray 1.40A ) 3P35 (X-ray 2.09A ) 3P36 (X-ray 1.59A ) 3P37 (X-ray 2.38A ) 3Q1I (X-ray 1.40A ) 3RQ7 (X-ray 1.55A ) 3THB (X-ray 2.50A ) 4A4L (X-ray 2.35A ) 4A4O (X-ray 2.70A ) 4DFW (X-ray 1.55A ) 4E67 (X-ray 2.10A ) 4E9C (X-ray 1.70A ) 4E9D (X-ray 2.75A ) 4H5X (X-ray 1.95A ) 4H71 (X-ray 1.93A ) 4HAB (X-ray 2.65A ) 4HCO (X-ray 2.75A ) 4HY2 (X-ray 2.00A ) 4J52 (X-ray 2.30A ) 4J53 (X-ray 2.50A ) 4LKL (X-ray 1.58A ) 4LKM (X-ray 2.00A ) 4O56 (X-ray 1.80A ) 4O6W (X-ray 1.45A ) 4O9W (X-ray 1.69A ) 4RCP (X-ray 1.60A ) 4WHH (X-ray 1.90A ) 4WHK (X-ray 1.80A ) 4WHL (X-ray 2.71A ) 4X9R (X-ray 1.40A ) 4X9V (X-ray 1.43A ) 4X9W (X-ray 1.80A ) 5J19 (X-ray 2.00A ) 5NEI (X-ray 2.68A ) 5NFU (X-ray 1.81A ) 5NJE (X-ray 1.98A ) 5NMM (X-ray 2.02A ) 5NN1 (X-ray 1.78A ) 5NN2 (X-ray 1.81A ) 5TA6 (X-ray 2.50A ) 5TA8 (X-ray 2.60A ) 6AX4 (X-ray 1.45A ) 6GY2 (X-ray 3.11A ) 7MSO (X-ray 1.85A ) 7MX1 (X-ray 1.64A ) |
| DBSNP | rs35056440 rs16972799 rs45489499 rs45569335 rs56027600 rs34001032 rs34954545 |
| Subcellular location [CC] | Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:24018379}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:30715179}. Midbody {ECO:0000269|PubMed:30715179}. Note=localization at the centrosome starts at the G1/S transition (PubMed:24018379). During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGO1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle. Localization to the centrosome is required for S phase progression (PubMed:24018379). Colocalizes with HSF1 at the spindle poles during prometaphase (PubMed:18794143). {ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:24018379}. |
| Mouse PG classification | NA |
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