| Gene Information | |
|---|---|
| Gene Name | ACTG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 376 |
| Protein Names | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000163017 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P63267 |
| Gene Card | ACTG2 |
| Uniprot ID | P63267 |
| Pfam | PF00022 |
| In ASD | no |
| Allosteric Prediction | no (-0.488879663) |
| Ortholog in Animals | Alpaca_ ACTG2 ( ortholog_one2one ) Dog_ DGUOK ( ortholog_one2one ) GuineaPig_ ACTG2 ( ortholog_one2one ) Macaque_ ACTG2 ( ortholog_one2one ) Mouse_ Actg2 ( ortholog_one2one ) Pig_ ACTG2 ( ortholog_one2one ) Rat_ Actg2 ( ortholog_one2one ) Rabbit_ ACTG2 ( ortholog_one2one ) |
| Ohnologs | ACTA2, ACTC1, ACTA1 |
| Paralogs | ACTA2, ACTC1, ACTBL2, ACTR1A, ACTB, ACTG1, ACTR5, ACTL9, ACTR3, ACTL7A, ACTL7B, ACTL8, ACTA1, ACTL6B, ACTR3B, ACTR3C, ACTRT2, ACTR8, ACTR1B, ACTL6A, ACTR2, ACTR6, ACTRT1, ACTRT3, ACTL10, ACTR10 |
| Tissue | sigmoid.colon |
| Tissue Specificity | In the intestine, abundantly expressed in smooth muscle cells of muscularis mucosa and muscularis propria. Also detected in intestinal vascular smooth muscle cells. {ECO:0000269|PubMed:26647307}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.059587(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6JAT (X-ray 2.71A ) |
| DBSNP | rs587777385 rs587777386 rs864309490 rs864309491 rs587777388 rs587777383 rs78001248 rs587777384 rs587777384 rs864309492 rs587777387 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. |
| Mouse PG classification | NA |
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