Gene Information
Gene NameGLRA2
OrganismHomo sapiens (Human)
Gene Length452
Protein NamesGlycine receptor subunit alpha-2
Target Nameglycine receptor subunit alpha-2
Target TypeNA
Gene Age886 ( ENSG00000101958 )
Evolutionary StageEuk+Bac
AlphaFoldDBP23416
Gene CardGLRA2
Uniprot IDP23416
PfamPF02931; PF02932
In ASDno
Allosteric Predictionyes (0.950547163)
Ortholog in AnimalsAlpaca_ GLRA2 ( ortholog_one2one )
Dog_ GLRA2 ( ortholog_one2one )
GuineaPig_ GLRA2 ( ortholog_one2one )
Macaque_ GLRA2 ( ortholog_one2one )
Mouse_ Glra2 ( ortholog_one2one )
Pig_ GLRA2 ( ortholog_one2one )
Rat_ Glra2 ( ortholog_one2one )
Rabbit_ GLRA2 ( ortholog_one2one )
OhnologsGLRA4, GABRP, GLRB, GABRR2, GLRA3, GABRA6, GLRA1
ParalogsCHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5BKF  (EM  3.60A  )  5BKG  (EM  3.80A  )  7KUY  (EM  3.60A  )  7L31  (EM  3.80A  ) 
DBSNP NA 
Subcellular location [CC]Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q7TNC8};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000250|UniProtKB:Q7TNC8}. Cell membrane {ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:23895467, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:26370147};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell projection {ECO:0000250|UniProtKB:Q7TNC8}.
Mouse PG classificationNA
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