| Gene Information | |
|---|---|
| Gene Name | PLG |
| Organism | Homo sapiens (Human) |
| Gene Length | 810 |
| Protein Names | Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] |
| Target Name | plasminogen |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000122194 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P00747 |
| Gene Card | PLG |
| Uniprot ID | P00747 |
| Pfam | PF00051; PF00024; PF00089 |
| In ASD | yes |
| Allosteric Prediction | yes (1.265687763) |
| Ortholog in Animals | Alpaca_ PLG ( ortholog_one2one ) Dog_ PLG ( ortholog_one2one ) GuineaPig_ PLG ( ortholog_one2one ) Macaque_ PLG ( ortholog_one2one ) Mouse_ Plg ( ortholog_one2one ) Pig_ PLG ( ortholog_one2one ) Rat_ Plg ( ortholog_one2one ) Rabbit_ PLG ( ortholog_one2one ) |
| Ohnologs | HGF |
| Paralogs | PLGLB1, PLGLB2, OVCH1, PLAT, PRSS48, TMPRSS12, GZMM, KLK15, PRSS37, PRSS27, PRSS33, PRSS57, PRSS50, KLK9 |
| Tissue | liver |
| Tissue Specificity | Present in plasma and many other extracellular fluids. It is synthesized in the liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1B2I (NMR - ) 1BML (X-ray 2.90A ) 1BUI (X-ray 2.65A ) 1CEA (X-ray 2.06A ) 1CEB (X-ray 2.07A ) 1DDJ (X-ray 2.00A ) 1HPJ (NMR - ) 1HPK (NMR - ) 1I5K (X-ray 2.70A ) 1KI0 (X-ray 1.75A ) 1KRN (X-ray 1.67A ) 1L4D (X-ray 2.30A ) 1L4Z (X-ray 2.80A ) 1PK4 (X-ray 1.90A ) 1PKR (X-ray 2.48A ) 1PMK (X-ray 2.25A ) 1QRZ (X-ray 2.00A ) 1RJX (X-ray 2.30A ) 2DOH (X-ray 2.30A ) 2DOI (X-ray 3.10A ) 2KNF (NMR - ) 2L0S (NMR - ) 2PK4 (X-ray 2.25A ) 3UIR (X-ray 2.78A ) 4A5T (X-ray 3.49A ) 4CIK (X-ray 1.78A ) 4DCB (X-ray 2.03A ) 4DUR (X-ray 2.45A ) 4DUU (X-ray 5.20A ) 5HPG (X-ray 1.66A ) 5UGD (X-ray 1.38A ) 5UGG (X-ray 1.20A ) 6D3X (X-ray 1.80A ) 6D3Y (X-ray 1.32A ) 6D3Z (X-ray 2.00A ) 6D40 (X-ray 1.43A ) 6OG4 (X-ray 1.70A ) 6OQJ (NMR - ) 6OQK (NMR - ) 6Q1U (X-ray 2.35A ) 6UZ4 (NMR - ) 6UZ5 (NMR - ) 7E50 (X-ray 1.95A ) |
| DBSNP | rs73015965 rs1049573 rs4252070 rs143079629 rs4252186 rs770198253 rs121918030 rs4252187 rs889957249 rs121918028 rs4252119 rs1804181 rs4252125 rs4252128 rs4252129 rs121918029 rs121918027 rs17857492 rs1582955358 rs121918033 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:10077593, ECO:0000269|PubMed:14699093}. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface. |
| Mouse PG classification | NA |
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