Gene Information
Gene NamePLEKHN1
OrganismHomo sapiens (Human)
Gene Length611
Protein NamesPleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)
Target NameNA
Target TypeNA
Gene Age382 ( ENSG00000187583 )
Evolutionary StageVertebrata
AlphaFoldDBQ494U1
Gene CardPLEKHN1
Uniprot IDQ494U1
PfamNA
In ASDno
Allosteric Predictionno (-1.93898525)
Ortholog in AnimalsAlpaca_ PLEKHN1 ( ortholog_one2many )
Dog_ PLEKHN1 ( ortholog_one2one )
GuineaPig_ PLEKHN1 ( ortholog_one2one )
Macaque_ PLEKHN1 ( ortholog_one2one )
Mouse_ Plekhn1 ( ortholog_one2one )
Pig_ PLEKHN1 ( ortholog_one2one )
Rat_ Plekhn1 ( ortholog_one2one )
OhnologsNA
ParalogsMCF2L2, VAV1, PLEKHG4, TIAM2, ARHGEF40, ARHGEF25, VAV2, VAV3, SPATA13, ARHGEF9, ARHGEF6, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, TIAM1, MCF2, KALRN, ARHGEF7, MCF2L, TRIO
Tissueskin, esophagus, cervix, tongue, zone.of.skin, esophagus.mucosa, lower.leg.skin, suprapubic.skin, vagina
Tissue SpecificityUbiquitous (PubMed:18191643). Epressed in several cancer cell lines of differing origin (PubMed:29531808). {ECO:0000269|PubMed:18191643, ECO:0000269|PubMed:29531808}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs3829740 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:25043870};
Lipid-anchor {ECO:0000269|PubMed:25043870}. Mitochondrion {ECO:0000269|PubMed:27616329, ECO:0000269|PubMed:29531808}. Mitochondrion membrane {ECO:0000269|PubMed:18191643, ECO:0000269|PubMed:29180010}. Note=Interaction with C1QBP and phosphorylation is essential for its mitochondrial localization. Localizes on the microtubule in the form of small granules. {ECO:0000269|PubMed:18191643}.
Mouse PG classificationNA
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