| Gene Information | |
|---|---|
| Gene Name | ARHGAP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 464 |
| Protein Names | Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000241484 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P85298 |
| Gene Card | ARHGAP8 |
| Uniprot ID | P85298 |
| Pfam | PF13716; PF00620 |
| In ASD | no |
| Allosteric Prediction | no (-0.79732537) |
| Ortholog in Animals | Alpaca_ ARHGAP8 ( ortholog_one2one ) Dog_ ARHGAP8 ( ortholog_one2one ) GuineaPig_ ARHGAP8 ( ortholog_one2one ) Macaque_ ARHGAP8 ( ortholog_one2one ) Mouse_ Arhgap8 ( ortholog_one2one ) Pig_ ARHGAP8 ( ortholog_one2one ) Rat_ Arhgap8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARHGAP1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in kidney and placenta. Also expressed in colon, skeletal muscle, small intestine, stomach, and testis. Not detected in brain, liver or spleen. Overexpressed in the majority of colorectal tumors examined. {ECO:0000269|PubMed:15225876}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16992915 rs6007344 rs2071762 rs9614957 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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