Gene Information
Gene NamePLEKHF2
OrganismHomo sapiens (Human)
Gene Length249
Protein NamesPleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000175895 )
Evolutionary StageEukaryota
AlphaFoldDBQ9H8W4
Gene CardPLEKHF2
Uniprot IDQ9H8W4
PfamPF01363; PF00169
In ASDno
Allosteric Predictionno (-1.359338935)
Ortholog in AnimalsAlpaca_ PLEKHF2 ( ortholog_one2one )
GuineaPig_ PLEKHF2 ( ortholog_one2one )
Macaque_ PLEKHF2 ( ortholog_one2one )
Mouse_ Plekhf2 ( ortholog_one2one )
Pig_ PLEKHF2 ( ortholog_one2one )
Rat_ Plekhf2 ( ortholog_one2one )
OhnologsPLEKHF1
ParalogsRUFY1, PLEKHF1, ZFYVE1, ZFYVE26, ZFYVE28, RUNDC3B, RUFY2, PLEKHM2, RUFY3, RUNDC3A, ZFYVE16, SNX29, ZFYVE19
TissueNA
Tissue SpecificityExpressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells. {ECO:0000269|PubMed:18288467}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Early endosome membrane {ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767};
Peripheral membrane protein {ECO:0000305|PubMed:19995552, ECO:0000305|PubMed:22816767}. Endoplasmic reticulum {ECO:0000269|PubMed:18288467}. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots (PubMed:19995552). May translocate to the endoplasmic reticulum in the early phase of apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552}.
Mouse PG classificationNA
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