| Gene Information | |
|---|---|
| Gene Name | PLEKHB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 243 |
| Protein Names | Pleckstrin homology domain-containing family B member 1 (PH domain-containing family B member 1) (Evectin-1) (PH domain-containing protein in retina 1) (PHRET1) (Pleckstrin homology domain retinal protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000021300 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9UF11 |
| Gene Card | PLEKHB1 |
| Uniprot ID | Q9UF11 |
| Pfam | PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.914961256) |
| Ortholog in Animals | Alpaca_ PLEKHB1 ( ortholog_one2one ) Dog_ PLEKHB1 ( ortholog_one2one ) GuineaPig_ PLEKHB1 ( ortholog_one2one ) Macaque_ PLEKHB1 ( ortholog_one2one ) Mouse_ Plekhb1 ( ortholog_one2one ) Pig_ PLEKHB1 ( ortholog_one2one ) Rat_ Plekhb1 ( ortholog_one2one ) Rabbit_ PLEKHB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PLEKHB2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in retina and brain. Levels are very low or not detectable in all other tissues tested. {ECO:0000269|PubMed:10585447}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:10585447}. Cytoplasm {ECO:0000250|UniProtKB:Q9QYE9}. Note=Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (By similarity). Membrane-associated (PubMed:10585447). Highly expressed in the outer segments of photoreceptor cells, both in rods and cones (PubMed:10585447). {ECO:0000250|UniProtKB:Q9QYE9, ECO:0000269|PubMed:10585447}. |
| Mouse PG classification | NA |
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