| Gene Information | |
|---|---|
| Gene Name | PLEC |
| Organism | Homo sapiens (Human) |
| Gene Length | 4684 |
| Protein Names | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000178209 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | PLEC |
| Uniprot ID | Q15149 |
| Pfam | PF00307; PF00681; PF03501; PF17902; PF18373 |
| In ASD | no |
| Allosteric Prediction | no (-0.609368628) |
| Ortholog in Animals | Alpaca_ PLEC ( ortholog_one2one ) Dog_ PLEC ( ortholog_one2one ) GuineaPig_ PLEC ( ortholog_one2one ) Macaque_ PLEC ( ortholog_one2one ) Mouse_ Plec ( ortholog_one2one ) Pig_ PLEC ( ortholog_one2one ) Rat_ Plec ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DSP, SPTBN5, ACTN4, MICAL2, DMD, SYNE3, GAS2L2, SPTBN2, FLNB, SPTAN1, SYNE2, EPPK1, SYNE1, CLMN, DYTN, MICAL3, PKHD1, SMTNL2, DRP2, UTRN, PKHD1L1, ACTN2, ACTN3, MICAL1, SPTBN1, MACF1, ACTN1, DST, SPTB, GAS2L3, FLNC, FLNA, DTNA, SPTA1, DTNB, SPTBN4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in muscle, heart, placenta and spinal cord. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1MB8 (X-ray 2.15A ) 2N03 (NMR - ) 2ODU (X-ray 2.30A ) 2ODV (X-ray 2.05A ) 3F7P (X-ray 2.75A ) 3PDY (X-ray 2.22A ) 3PE0 (X-ray 2.95A ) 4GDO (X-ray 1.70A ) 4Q58 (X-ray 4.00A ) 4Q59 (X-ray 2.30A ) 5J1F (X-ray 3.00A ) 5J1G (X-ray 1.80A ) 5J1H (X-ray 2.80A ) 5J1I (X-ray 2.80A ) |
| DBSNP | rs200335928 rs11136336 rs3135109 rs11136334 rs55895668 rs200543521 rs80338756 rs34893635 rs7002002 rs7833924 rs35723243 rs6558407 rs35027700 rs35858667 rs34725742 rs35261863 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12482924}. Cell junction, hemidesmosome {ECO:0000269|PubMed:12482924}. |
| Mouse PG classification | LPG |
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