| Gene Information | |
|---|---|
| Gene Name | PLD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 933 |
| Protein Names | Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) |
| Target Name | phospholipase d2 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000129219 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14939 |
| Gene Card | PLD2 |
| Uniprot ID | O14939 |
| Pfam | PF00614; PF13091; PF00787 |
| In ASD | yes |
| Allosteric Prediction | yes (1.208254033) |
| Ortholog in Animals | Alpaca_ PLD2 ( ortholog_one2one ) Dog_ PLD2 ( ortholog_one2one ) GuineaPig_ PLD2 ( ortholog_one2one ) Macaque_ PLD2 ( ortholog_one2one ) Mouse_ Pld2 ( ortholog_one2one ) Pig_ PLD2 ( ortholog_one2one ) Rat_ Pld2 ( ortholog_one2one ) Rabbit_ PLD2 ( ortholog_one2one ) |
| Ohnologs | PLD1 |
| Paralogs | PLD1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9582313}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6OHM (X-ray 1.90A ) 6OHO (X-ray 2.00A ) 6OHP (X-ray 2.60A ) 6OHQ (X-ray 2.69A ) 6OHS (X-ray 3.20A ) |
| DBSNP | rs2286672 rs1052748 rs17854914 rs11545163 rs3764897 rs3764897 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P97813}; Lipid-anchor {ECO:0000250|UniProtKB:P97813}. |
| Mouse PG classification | NA |
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