| Gene Information | |
|---|---|
| Gene Name | NCR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 201 |
| Protein Names | Natural cytotoxicity triggering receptor 3 (Activating natural killer receptor p30) (Natural killer cell p30-related protein) (NK-p30) (NKp30) (CD antigen CD337) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000204475 ) 3 ( ENSG00000206430 ) 3 ( ENSG00000223833 ) 3 ( ENSG00000225211 ) 3 ( ENSG00000236315 ) 3 ( ENSG00000236979 ) 3 ( ENSG00000237103 ) 3 ( ENSG00000237808 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O14931 |
| Gene Card | NCR3 |
| Uniprot ID | O14931 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-1.164396963) |
| Ortholog in Animals | Alpaca_ NCR3 ( ortholog_one2one ) Dog_ NCR3 ( ortholog_one2one ) Macaque_ NCR3 ( ortholog_one2one ) Rat_ Ncr3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TIGIT, CD200, NECTIN1, NECTIN2, CADM3, NECTIN4, CADM2, CRTAM, NECTIN3, CADM4, SMAGP, CADM1, CD226, PVR |
| Tissue | appendix, bone.marrow, lymph.node, spleen |
| Tissue Specificity | Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. {ECO:0000269|PubMed:10562324, ECO:0000269|Ref.2}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3NOI (X-ray 1.84A ) 3PV6 (X-ray 2.30A ) 6YJP (X-ray 3.10A ) |
| DBSNP | rs11575840 rs3179003 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10562324}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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